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微流控技术在即时兽医诊断中的应用机遇与挑战

Opportunities and challenges for the application of microfluidic technologies in point-of-care veterinary diagnostics.

作者信息

Busin Valentina, Wells Beth, Kersaudy-Kerhoas Maïwenn, Shu Wenmaio, Burgess Stewart T G

机构信息

Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, EH26 0PZ, United Kingdom; School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom.

Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, EH26 0PZ, United Kingdom.

出版信息

Mol Cell Probes. 2016 Oct;30(5):331-341. doi: 10.1016/j.mcp.2016.07.004. Epub 2016 Jul 16.

Abstract

There is a growing need for low-cost, rapid and reliable diagnostic results in veterinary medicine. Point-of-care (POC) tests have tremendous advantages over existing laboratory-based tests, due to their intrinsic low-cost and rapidity. A considerable number of POC tests are presently available, mostly in dipstick or lateral flow formats, allowing cost-effective and decentralised diagnosis of a wide range of infectious diseases and public health related threats. Although, extremely useful, these tests come with some limitations. Recent advances in the field of microfluidics have brought about new and exciting opportunities for human health diagnostics, and there is now great potential for these new technologies to be applied in the field of veterinary diagnostics. This review appraises currently available POC tests in veterinary medicine, taking into consideration their usefulness and limitations, whilst exploring possible applications for new and emerging technologies, in order to widen and improve the range of POC tests available.

摘要

兽医学对低成本、快速且可靠的诊断结果的需求日益增长。即时检测(POC)因其固有的低成本和快速性,相对于现有的基于实验室的检测具有巨大优势。目前有相当数量的即时检测方法,大多为试纸条或侧向流动形式,可对多种传染病及公共卫生相关威胁进行经济高效且分散式的诊断。尽管这些检测极为有用,但也存在一些局限性。微流体领域的最新进展为人类健康诊断带来了新的、令人兴奋的机遇,如今这些新技术在兽医诊断领域也具有巨大的应用潜力。本综述评估了兽医学中目前可用的即时检测方法,考虑了它们的实用性和局限性,同时探索新兴技术的可能应用,以拓宽和改进可用的即时检测方法的范围。

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