Osmancevic Amra, Demeke Taye, Gillstedt Martin, Angesjö Eva, Sinclair Håkan, Abd El-Gawad Gamal, Landin-Wilhelmsen Kerstin
Department of Dermatology, Sahlgrenska University Hospital, at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Hjällbo Primary Health Care, Gothenburg, Sweden.
Clin Endocrinol (Oxf). 2016 Oct;85(4):535-43. doi: 10.1111/cen.13097. Epub 2016 Jun 2.
There is limited information about the prevalence of vitamin D deficiency and the effects of treatment on immigrants. The effects of oral vitamin D intake and UVB treatment on vitamin D status in healthy Somali women living in Sweden were analysed.
Two studies were carried out; a randomized, double-blind, placebo-controlled study, with oral drops of 800 IU and 1600 IU cholecalciferol and similar amounts of placebo given daily during 12 weeks and a single-blind, placebo-controlled study, using UVB (4·3-8·7 J/cm(2) ) or Woods lamp (placebo) on the upper body, or the face and hands.
One-hundred fourteen Somali women, mean age 34 years, latitude 0-10°N, living in Sweden >2 years, latitude 57°N, participated.
Serum 25-hydroxyvitamin D (S-25(OH)D) was monitored before, every 6 weeks and at 3 months after treatment.
The majority of the women (n = 83, 73%) were vitamin D-deficient, S-25(OH)D < 25 nmol/l at start. There was a dose-dependent increase in S-25(OH)D levels (P = 0·001, stratified Jonckheere-Terpstra test) with a mean increase after twelve weeks in women treated with 800 IU/day and women treated with 1600 IU/day of 18 nmol/l (95% CI: 6-29, median = 17) and 29 nmol/l (95% CI: 17-42, median = 34), respectively. S-25(OH)D decreased during follow-up but remained above baseline levels. The placebo group remained unchanged throughout the study. UVB treatment increased S-25(OH)D dose-dependently after 6 weeks (P = 0·03, Jonckheere-Terpstra test).
Vitamin D deficiency was common in immigrants living at higher latitudes. Vitamin D treatment increased S-25(OH)D levels dose-dependently during 3 months. The effect was maintained for another 3 months. At least 1600 IU/day is recommended. The dropout rate was high.
关于维生素D缺乏症的患病率以及治疗对移民的影响，相关信息有限。分析了口服维生素D摄入和紫外线B（UVB）治疗对居住在瑞典的健康索马里女性维生素D状态的影响。
开展了两项研究；一项随机、双盲、安慰剂对照研究，每日给予800国际单位（IU）和1600 IU胆钙化醇口服滴剂以及等量安慰剂，持续12周；另一项单盲、安慰剂对照研究，对上半身或面部及手部使用UVB（4·3 - 8·7 J/cm²）或伍德灯（安慰剂）。
114名索马里女性参与，平均年龄34岁，来自北纬0 - 10°，在瑞典居住超过2年，瑞典纬度为北纬57°。
在治疗前、每6周以及治疗后3个月监测血清25 - 羟基维生素D（S - 25(OH)D）。
大多数女性（n = 83，73%）在开始时维生素D缺乏，S - 25(OH)D < 25 nmol/l。S - 25(OH)D水平呈剂量依赖性增加（P = 0·001，分层Jonckheere - Terpstra检验），每日接受800 IU和1600 IU治疗的女性在12周后平均增加量分别为18 nmol/l（95%置信区间：6 - 29，中位数 = 17）和29 nmol/l（95%置信区间：17 - 42，中位数 = 34）。S - 25(OH)D在随访期间下降，但仍高于基线水平。安慰剂组在整个研究过程中保持不变。UVB治疗在6周后使S - 25(OH)D呈剂量依赖性增加（P = 0·03，Jonckheere - Terpstra检验）。
居住在高纬度地区的移民中维生素D缺乏症很常见。维生素D治疗在3个月内使S - 25(OH)D水平呈剂量依赖性增加。这种效果持续了另外3个月。建议每日至少摄入1600 IU。脱落率很高。
