El-Kady Abeer M, Farag Mohammad M, El-Rashedi Ahlam M I
Biomaterials Department, National Research Center, 33 El-Bohooth St., Dokki 12622, Cairo, Egypt; Advanced Materials and Nanotechnology Lab., Center of Excellence, National Research Center, Dokki 12622, Cairo, Egypt.
Biomaterials Department, National Research Center, 33 El-Bohooth St., Dokki 12622, Cairo, Egypt; Advanced Materials and Nanotechnology Lab., Center of Excellence, National Research Center, Dokki 12622, Cairo, Egypt.
Eur J Pharm Sci. 2016 Aug 25;91:243-50. doi: 10.1016/j.ejps.2016.05.004. Epub 2016 May 4.
Lithium modified bioactive glass nanoparticles were prepared for multiple deliveries of lithium ions and drugs. The particle size, structure and thermal behavior of nanoparticles were analyzed using TEM, FTIR and DSC respectively. The porosity% and specific surface area of glass nanoparticles were about 68.6% and 224.92 (m(2)/g), respectively. The in vitro bioactivity evaluation in SBF revealed that glass nanoparticles were capable of inducing apatite layer over their surfaces. This could be considered as a good indicator for their future abilities to regenerate bone tissue in vivo. Also, lithium ions were released from glass nanoparticles via diffusion controlled process which could activate Wnt signaling pathway and enhance osteogenesis. As a final point, the possibility of utilizing the glass nanoparticles as a controlled delivery device for vancomycin or 5-FU was verified. Fitting vancomycin or 5-FU release profiles to various mathematical models pointed out that both drugs were released by a diffusion-controlled mode.
制备了锂改性生物活性玻璃纳米颗粒用于锂离子和药物的多次递送。分别使用透射电子显微镜（TEM）、傅里叶变换红外光谱仪（FTIR）和差示扫描量热仪（DSC）分析了纳米颗粒的粒径、结构和热行为。玻璃纳米颗粒的孔隙率%和比表面积分别约为68.6%和224.92（m²/g）。在模拟体液（SBF）中的体外生物活性评估表明，玻璃纳米颗粒能够在其表面诱导形成磷灰石层。这可被视为其未来在体内再生骨组织能力的良好指标。此外，锂离子通过扩散控制过程从玻璃纳米颗粒中释放出来，这可以激活Wnt信号通路并增强成骨作用。最后，验证了将玻璃纳米颗粒用作万古霉素或5-氟尿嘧啶（5-FU）控释载体的可能性。将万古霉素或5-FU的释放曲线拟合到各种数学模型表明，两种药物均通过扩散控制模式释放。
