基因中的遗传变异与先兆子痫风险：一项初步研究。
Genetic Variations in Gene and Risk of Preeclampsia: A Pilot Study.
作者信息
He Dong, Peng Xianglan, Xie Hongkai, Peng Rui, Li Qixuan, Guo Yitong, Wang Wei, He Hong, Chen Yang
机构信息
Guangdong Provincial Key Laboratory of Pathogenesis of Heart and Spleen and Prescription Drugs Research, Department of Pharmacology, School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Department of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
出版信息
J Clin Med. 2023 Feb 14;12(4):1509. doi: 10.3390/jcm12041509.
Preeclampsia (PE) is a typical hypertensive disorders of pregnancy (HDP) which can cause substantial morbidity and mortality in both pregnant women and fetuses. The renin-angiotensin system (RAS) genes are the main HDP-causing genes, and Angiotensinogen (AGT) as the initial substrate can directly reflect the activity of the entire RAS. However, the association between SNPs and PE risk has rarely been confirmed. This study was carried out to determine whether SNPs could affect the risk of PE in 228 cases and 358 controls. The genotyping result revealed that the rs7079 TT carrier was related to increased PE risk. Further stratified analysis illustrated that the rs7079 TT genotype significantly increased the PE risk in subgroups of Age < 35, BMI < 25, Albumin (ALB) ≥ 30 and Aspartate aminotransferase (AST) < 30. These findings demonstrated that the rs7079 might be a promising candidate SNP strongly associated with PE susceptibility.
子痫前期（PE）是一种典型的妊娠期高血压疾病（HDP），可导致孕妇和胎儿出现严重的发病和死亡情况。肾素-血管紧张素系统（RAS）基因是导致HDP的主要基因，而血管紧张素原（AGT）作为初始底物可直接反映整个RAS的活性。然而，单核苷酸多态性（SNPs）与PE风险之间的关联很少得到证实。本研究旨在确定SNPs是否会影响228例病例和358例对照中PE的风险。基因分型结果显示，rs7079 TT携带者与PE风险增加有关。进一步的分层分析表明，rs7079 TT基因型在年龄<35岁、体重指数（BMI）<25、白蛋白（ALB）≥30和天冬氨酸转氨酶（AST）<30的亚组中显著增加了PE风险。这些发现表明，rs7079可能是一个与PE易感性密切相关的有前景的候选SNP。
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