Meddahi-Pellé Anne, Legrand Aurélie, Marcellan Alba, Louedec Liliane, Letourneur Didier, Leibler Ludwik
Inserm U1148, LVTS; Université Paris 7, Université Paris 13, Sorbonne Paris Cité, Hôpital Bichat, 46 rue rue H Huchard, 75018 Paris (France); Université Paris 13, Sorbonne Paris Cité, Paris (France).
Angew Chem Int Ed Engl. 2014 Jun 16;53(25):6369-73. doi: 10.1002/anie.201401043. Epub 2014 Apr 16.
Sutures are traumatic to soft connective tissues, such as liver or lungs. Polymer tissue adhesives require complex in vivo control of polymerization or cross-linking reactions and currently suffer from being toxic, weak, or inefficient within the wet conditions of the body. Herein, we demonstrate using Stöber silica or iron oxide nanoparticles that nanobridging, that is, adhesion by aqueous nanoparticle solutions, can be used in vivo in rats to achieve rapid and strong closure and healing of deep wounds in skin and liver. Nanoparticles were also used to fix polymer membranes to tissues even in the presence of blood flow, such as occurring after liver resection, yielding permanent hemostasis within a minute. Furthermore, medical devices and tissue engineering constructs were fixed to organs such as a beating heart. The simplicity, rapidity, and robustness of nanobridging bode well for clinical applications, surgery, and regenerative medicine.
缝线对肝脏或肺等软结缔组织具有创伤性。聚合物组织粘合剂需要在体内对聚合或交联反应进行复杂的控制，目前存在毒性、强度不足或在人体潮湿环境中效率低下的问题。在此，我们展示了使用斯托伯二氧化硅或氧化铁纳米颗粒进行纳米桥接，即通过水性纳米颗粒溶液实现粘附，可在大鼠体内用于快速、强力地闭合和愈合皮肤和肝脏的深部伤口。即使在存在血流的情况下，如肝切除术后，纳米颗粒也可用于将聚合物膜固定到组织上，在一分钟内实现永久性止血。此外，医疗设备和组织工程构建体可固定到跳动的心脏等器官上。纳米桥接的简单性、快速性和稳健性预示着其在临床应用、手术和再生医学方面具有良好前景。
