Pyo Jung-Soo, Sohn Jin Hee, Kang Guhyun
a Department of Pathology, Kangbuk Samsung Hospital , Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
b Department of Pathology , Inje University Sanggye Paik Hospital , Seoul , Republic of Korea.
Platelets. 2016 Dec;27(8):722-728. doi: 10.3109/09537104.2016.1169265. Epub 2016 May 9.
The aim of this study was to elucidate the diagnostic and prognostic roles of the mean platelet volume (MPV) in various malignant tumors through a systematic review and meta-analysis. The current study included 2,053 patients and 1,396 healthy subjects in 18 eligible studies. We performed a meta-analysis of MPV levels and the mean difference between healthy subjects and pre- and post-treatment patients. Subgroup analysis was conducted based on specific organs and platelet counts. In addition, the correlation between MPV and survival was investigated. The pooled MPVs of healthy subjects, pre-treatment, and post-treatment patients were 8.428 fL (95% confidence interval [CI] 8.118-8.738), 8.831 fL (95% CI 8.582-9.087), and 8.521 fL (95% CI 8.162-8.880), respectively. The mean difference in MPV between healthy subjects and pre-treatment patients was 0.502 (95% CI 0.285-0.719, P < 0.001). However, in lung cancer, the mean difference between pre-treatment patients and healthy subjects was -0.352 (95% CI -0.763-0.060, P = 0.094). The pooled MPV of post-treatment patients was significantly decreased compared to pre-treatment patients. There was no correlation between MPV and disease-free survival rate (hazard ratio 1.033, 95% CI 0.369-2.895). Our results showed that the MPV level was significantly higher in malignant tumors than in healthy subjects and was decreased after treatment. Further cumulative studies will be required before MPV levels can be applied for screening malignant tumors and predicting prognosis.
本研究旨在通过系统评价和荟萃分析阐明平均血小板体积（MPV）在各种恶性肿瘤中的诊断和预后作用。当前研究纳入了18项符合条件的研究中的2053例患者和1396例健康受试者。我们对MPV水平以及健康受试者与治疗前和治疗后患者之间的平均差异进行了荟萃分析。基于特定器官和血小板计数进行了亚组分析。此外，还研究了MPV与生存率之间的相关性。健康受试者、治疗前患者和治疗后患者的合并MPV分别为8.428 fL（95%置信区间[CI] 8.118 - 8.738）、8.831 fL（95% CI 8.582 - 9.087）和8.521 fL（95% CI 8.162 - 8.880）。健康受试者与治疗前患者之间MPV的平均差异为0.502（95% CI 0.285 - 0.719，P < 0.001）。然而，在肺癌中，治疗前患者与健康受试者之间的平均差异为 -0.352（95% CI -0.763 - 0.060，P = 0.094）。治疗后患者的合并MPV与治疗前患者相比显著降低。MPV与无病生存率之间无相关性（风险比1.033，95% CI 0.369 - 2.895）。我们的结果表明，恶性肿瘤患者的MPV水平显著高于健康受试者，且治疗后降低。在MPV水平可用于筛查恶性肿瘤和预测预后之前，还需要进一步的累积研究。
