Roźynkowa D, Stepień J, Kowalewski J, Nowakowski A
Hum Genet. 1977 Dec 23;39(3):293-301. doi: 10.1007/BF00295422.
The R-banding pattern of the chromosomes of 31 patients hospitalized in the Hematologic Clinic for myeloid leukemia were studied before chemotherapy. This analysis permitted identification of one unusual 3-chromosome rearrangement t(3;9;22) in addition to 25 classic forms of (22q-;9q+) translocation accompanied by the specific Ph' chromosome in chronic granulocytic leukemia patients, independent of the blastic course of the disease. During blastic crisis observed in 6 patients, extra 8 and 10 chromosomes, monosomy for chromosome 17, isochromosomes 17q, translocation (12q;13q), and additional Ph' were noted. The nonrandomness of these findings is determined from results published by other authors. Their significance for the cellular phenotype is presently unknown.
对31名因髓系白血病入住血液科门诊的患者在化疗前进行了染色体R带模式研究。该分析除了发现25例慢性粒细胞白血病患者中伴有特异性Ph'染色体的经典(22q-;9q+)易位形式外，还鉴定出一种不寻常的3号染色体重排t(3;9;22)，且与疾病的原始细胞进程无关。在6例患者出现原始细胞危象期间，发现了额外的8号和10号染色体、17号染色体单体、17q等臂染色体、(12q;13q)易位以及额外的Ph'染色体。这些发现的非随机性是根据其他作者发表的结果确定的。它们对细胞表型的意义目前尚不清楚。
