Pan Mei-Ren, Li Kaiyi, Lin Shiaw-Yih, Hung Wen-Chun
Graduate Institute of Clinical Medicine, College of Medicine, Kaohsoung Medical University, Kaohsiung 807, Taiwan.
The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Int J Mol Sci. 2016 May 6;17(5):685. doi: 10.3390/ijms17050685.
Mammalian cells evolve a delicate system, the DNA damage response (DDR) pathway, to monitor genomic integrity and to prevent the damage from both endogenous end exogenous insults. Emerging evidence suggests that aberrant DDR and deficient DNA repair are strongly associated with cancer and aging. Our understanding of the core program of DDR has made tremendous progress in the past two decades. However, the long list of the molecules involved in the DDR and DNA repair continues to grow and the roles of the new "dots" are under intensive investigation. Here, we review the connection between DDR and DNA repair and aging and discuss the potential mechanisms by which deficient DNA repair triggers systemic effects to promote physiological or pathological aging.
哺乳动物细胞进化出一种精密的系统——DNA损伤反应（DDR）通路，以监测基因组完整性，并防止其受到内源性和外源性损伤。越来越多的证据表明，异常的DDR和DNA修复缺陷与癌症和衰老密切相关。在过去二十年里，我们对DDR核心程序的理解取得了巨大进展。然而，参与DDR和DNA修复的分子清单仍在不断增加，这些新“节点”的作用正受到深入研究。在此，我们综述DDR与DNA修复及衰老之间的联系，并讨论DNA修复缺陷引发系统性效应以促进生理或病理衰老的潜在机制。
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