Department of Virology, Immunology, Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, USA.
Department of Medicine and Virology, Immunology, Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, USA.
Viruses. 2024 May 9;16(5):751. doi: 10.3390/v16050751.
People with HIV exhibit persistent inflammation that correlates with HIV-associated comorbidities including accelerated aging, increased risk of cardiovascular disease, and neuroinflammation. Mechanisms that perpetuate chronic inflammation in people with HIV undergoing antiretroviral treatments are poorly understood. One hypothesis is that the persistent low-level expression of HIV proviruses, including RNAs generated from defective proviral genomes, drives the immune dysfunction that is responsible for chronic HIV pathogenesis. We explore factors during HIV infection that contribute to the generation of a pool of defective proviruses as well as how HIV-1 mRNA and proteins alter immune function in people living with HIV.
HIV 感染者表现出持续的炎症，这与 HIV 相关的合并症有关，包括加速衰老、心血管疾病风险增加和神经炎症。抗逆转录病毒治疗的 HIV 感染者中持续慢性炎症的机制尚不清楚。一种假设是，HIV 前病毒的持续低水平表达，包括来自缺陷前病毒基因组的 RNA，驱动了导致慢性 HIV 发病机制的免疫功能障碍。我们探讨了 HIV 感染期间导致缺陷前病毒池产生的因素，以及 HIV-1 mRNA 和蛋白如何改变 HIV 感染者的免疫功能。
