Shenoy Divya, Packianathan Satyaseelan, Chen Allen M, Vijayakumar Srinivasan
University of Mississippi Medical School, Jackson, MS, USA.
University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA.
BMC Urol. 2016 May 10;16(1):19. doi: 10.1186/s12894-016-0137-7.
In 2012, the United States Preventative Services Task Force issued new guidelines recommending that male U.S. residents, irrespective of race, no longer be screened for prostate cancer. In African American men, the incidence of prostate cancer is almost 60 % higher and the mortality rate is two to three times greater than in Caucasians. The purpose of this study is to reduce African American men's prostate cancer burden by demonstrating they need separate screening guidelines.
We performed a PubMed search using the keywords: African American, Prostate cancer, Outcomes, Molecular markers, Prostate-specific Antigen velocity, PSA density, and to derive data relevant to our hypothesis.
In our literature review, we identified several aspects of prostate cancer that are different in Caucasian and African American men. These included prostate cancer incidence and outcome, the clinical course of the disease, serum PSA levels, genetic differences, and social barriers. It's also important to note that the USPSTF guidelines were based on two studies, one of which reported that only 4 % of its participants were African American. The other did not report demographic information, but used participants from seven European countries with small African American populations.
Given the above, we conclude that separate prostate cancer screening guidelines are greatly necessary to help save the lives of African Americans.
2012年，美国预防服务工作组发布了新指南，建议美国男性居民，无论种族如何，均不再进行前列腺癌筛查。在非裔美国男性中，前列腺癌的发病率比白种人高近60%，死亡率是白种人的两到三倍。本研究的目的是通过证明非裔美国男性需要单独的筛查指南来减轻他们的前列腺癌负担。
我们使用关键词“非裔美国人”“前列腺癌”“结果”“分子标志物”“前列腺特异性抗原速度”“PSA密度”在PubMed上进行搜索，以获取与我们假设相关的数据。
在我们的文献综述中，我们确定了前列腺癌在白种人和非裔美国男性中存在差异的几个方面。这些方面包括前列腺癌的发病率和结果、疾病的临床过程、血清PSA水平、基因差异以及社会障碍。还需要注意的是，美国预防服务工作组的指南基于两项研究，其中一项研究报告称其参与者中只有4%是非裔美国人。另一项研究没有报告人口统计学信息，但使用了来自七个欧洲国家且非裔美国人群体较少的参与者。
鉴于上述情况，我们得出结论，非常有必要制定单独的前列腺癌筛查指南，以帮助挽救非裔美国人的生命。
