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雄激素受体信号与 DNA 修复中的睾酮：敌是友非？

Testosterone in Androgen Receptor Signaling and DNA Repair: Enemy or Frenemy?

机构信息

Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

出版信息

Clin Cancer Res. 2016 Jul 1;22(13):3124-6. doi: 10.1158/1078-0432.CCR-16-0381. Epub 2016 May 10.

DOI:10.1158/1078-0432.CCR-16-0381
PMID:27166396
Abstract

Androgen suppression mediates transcriptional downregulation of DNA repair genes. Stimulation with supraphysiologic levels of dihydrotestosterone induces formation of lethal DNA breaks through recruitment of topoisomerase II enzymes to fragile DNA sites. Bipolar castration and stimulation that contributes to increasing DNA damage represents a novel strategy of sensitizing prostate cancer to cytotoxic therapies, including radiotherapy. Clin Cancer Res; 22(13); 3124-6. ©2016 AACRSee related article by Hedayati et al., p. 3310.

摘要

雄激素抑制介导 DNA 修复基因的转录下调。二氢睾酮的超生理水平刺激通过将拓扑异构酶 II 酶募集到脆弱的 DNA 位点诱导致死性 DNA 断裂的形成。双相去势和刺激导致 DNA 损伤增加，这代表了一种使前列腺癌对细胞毒性疗法（包括放射疗法）敏感的新策略。临床癌症研究; 22(13); 3124-6. ©2016AACR 参见 Hedayati 等人的相关文章，第 3310 页。

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