Liu Xin, Li Shuang, Lin Xuejun, Yan Kangkang, Zhao Longyu, Yu Qiong, Liu Xiaodong
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Department of Radiology and Radiation Oncology, China-Japan Union Hospital, Changchun, China; Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, China.
Iran Red Crescent Med J. 2016 Jan 1;18(2):e20960. doi: 10.5812/ircmj.20960. eCollection 2016 Feb.
Findings of recent studies have demonstrated a rapid increase of the incidence of papillary thyroid carcinoma (PTC), which accounts for nearly 80% of thyroid cancers.
The aim of this study was to explore the association between AXIN2 gene polymorphism and papillary thyroid carcinoma (PTC).
106 blood samples (56 PTC patients and 50 healthy controls) were drawn from China-Japan Union Hospital in Jilin province, China, during October 2010 to March 2011. A case-control study was designed to examine the association between AXIN2 and PTC. Seven tag single nucleotide polymorphisms (tag SNPs) in AXIN2 were selected and genotyped. Frequencies of different genotypes and alleles were analyzed between the patients and the controls, using the R × C column contingency table χ(2) test. The possible association of haplotypes constructed by the combined effects of two or more loci with PTC was analyzed through the UNPHASED 3.1.4 program.
Rs11655966, rs3923086 and rs7591 of AXIN2 showed significant associations with PTC (P < 0.05). The result of haplotypes analysis showed that rs11655966-rs3923086-rs4791169 had statistically significant differences between the two groups (P < 0.05).
Together with the functions of the target genes, we further elucidated that AXIN2 is associated with papillary thyroid carcinoma in the Chinese Han population.
近期研究结果显示，甲状腺乳头状癌（PTC）的发病率迅速上升，其占甲状腺癌的近80%。
本研究旨在探讨AXIN2基因多态性与甲状腺乳头状癌（PTC）之间的关联。
2010年10月至2011年3月期间，从中国吉林省中日联谊医院采集了106份血样（56例PTC患者和50例健康对照）。设计了一项病例对照研究，以检验AXIN2与PTC之间的关联。选择了AXIN2中的7个标签单核苷酸多态性（tag SNPs）并进行基因分型。使用R×C列联表χ²检验分析患者和对照之间不同基因型和等位基因的频率。通过UNPHASED 3.1.4程序分析由两个或更多位点的联合作用构建的单倍型与PTC的可能关联。
AXIN2的Rs11655966、rs3923086和rs7591与PTC显示出显著关联（P<0.05）。单倍型分析结果显示，两组之间rs11655966 - rs3923086 - rs4791169存在统计学显著差异（P<0.05）。
结合靶基因的功能，我们进一步阐明AXIN2与中国汉族人群的甲状腺乳头状癌相关。
