氧化应激对组织修复和再生的益处。
The benefits of oxidative stress for tissue repair and regeneration.
作者信息
Serras Florenci
机构信息
a Institute of Biomedicine of the University of Barcelona (IBUB) , Barcelona , Spain.
b Departament de Genètica, Facultat de Biologia , Universitat de Barcelona , Barcelona , Spain.
出版信息
Fly (Austin). 2016 Jul 2;10(3):128-33. doi: 10.1080/19336934.2016.1188232. Epub 2016 May 12.
Abstract
Recent work has strengthened Drosophila imaginal discs as a model system for regeneration studies. Evidence is accumulating that oxidative stress drives the cellular responses for repair and regeneration. Drosophila imaginal discs generate a burst of reactive oxygen species (ROS) upon damage that is necessary for the activation of the Jun N-terminal kinase (JNK) and p38 MAP kinase signaling pathways. Moreover, these pathways are pivotal in the activation of regenerative growth. A hypothetical mechanism of how the ROS are initiated, and how repair and regeneration is activated is discussed here.
摘要
近期的研究工作进一步巩固了果蝇成虫盘作为再生研究模型系统的地位。越来越多的证据表明，氧化应激驱动细胞的修复和再生反应。果蝇成虫盘在受损时会产生一阵活性氧（ROS），这对于激活Jun N端激酶（JNK）和p38丝裂原活化蛋白激酶信号通路是必需的。此外，这些通路在激活再生生长中起关键作用。本文讨论了ROS如何引发以及修复和再生如何被激活的一种假说机制。
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