Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
Nanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, Turkey.
Molecules. 2022 Oct 6;27(19):6642. doi: 10.3390/molecules27196642.
Elevated levels of oxidative stress are usually observed following injuries, leading to impaired tissue repair due to oxidation-related chronic inflammation. Several attempts have been made to manage this unfavorable situation, and the use of biomaterials with antioxidant activity is showing great promise in tissue engineering and regenerative medicine approaches. Bioactive glasses (BGs) are a versatile group of inorganic substances that exhibit an outstanding regenerative capacity for both hard and soft damaged tissues. The chemical composition of BGs provides a great opportunity for imparting specific biological activities to them. On this point, BGs may easily become antioxidant substances through simple physicochemical modifications. For example, particular antioxidant elements (mostly cerium (Ce)) can be added to the basic composition of the glasses. On the other hand, grafting natural antioxidant substances (e.g., polyphenols) on the BG surface is feasible for making antioxidant substitutes with promising results in vitro. Mesoporous BGs (MBGs) were demonstrated to have unique merits compared with melt-derived BGs since they make it possible to load antioxidants and deliver them to the desired locations. However, there are actually limited in vivo experimental studies on the capability of modified BGs for scavenging free radicals (e.g., reactive oxygen species (ROS)). Therefore, more research is required to determine the actual potential of BGs in decreasing oxidative stress and subsequently improving tissue repair and regeneration. The present work aims to highlight the potential of different types of BGs in modulating oxidative stress and subsequently improving tissue healing.
氧化应激水平通常在损伤后升高，导致氧化相关的慢性炎症导致组织修复受损。人们已经尝试了几种方法来应对这种不利情况，具有抗氧化活性的生物材料在组织工程和再生医学方法中显示出巨大的应用前景。生物活性玻璃（BGs）是一组多功能的无机物质，对硬组织和软组织损伤都具有出色的再生能力。BGs 的化学成分为其赋予特定的生物学活性提供了绝佳的机会。在这一点上，BGs 可以通过简单的物理化学修饰很容易地成为抗氧化物质。例如，可以在玻璃的基本组成中添加特定的抗氧化元素（主要是铈（Ce））。另一方面，在 BG 表面接枝天然抗氧化物质（例如多酚）可以制造出具有体外应用前景的抗氧化替代物。与熔融衍生的 BG 相比，介孔 BG（MBGs）具有独特的优点，因为它可以负载抗氧化剂并将其输送到所需的位置。然而，实际上对于改性 BG 清除自由基（例如活性氧物种（ROS））的能力的体内实验研究有限。因此，需要进一步的研究来确定 BG 在降低氧化应激和随后改善组织修复和再生方面的实际潜力。本研究旨在强调不同类型的 BG 在调节氧化应激和随后改善组织愈合方面的潜力。
