Department of Pharmacognosy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznan, Poland.
Nutrients. 2022 Jun 26;14(13):2647. doi: 10.3390/nu14132647.
Hesperidin and hesperetin are polyphenols that can be found predominantly in citrus fruits. They possess a variety of pharmacological properties such as neuroprotective and antidiabetic activity. However, the bioavailability of these compounds is limited due to low solubility and restricts their use as pro-healthy agents. This paper described the limitations resulting from the low bioavailability of the presented compounds and gathered the methods aiming at its improvement. Moreover, this work reviewed studies providing pieces of evidence for neuroprotective and antidiabetic properties of hesperidin and hesperetin as well as providing a detailed look into the significance of reported modes of action in chronic diseases. On account of a well-documented pro-healthy activity, it is important to look for ways to overcome the problem of poor bioavailability.
橙皮苷和橙皮素是主要存在于柑橘类水果中的多酚类化合物。它们具有多种药理活性，如神经保护和抗糖尿病活性。然而，由于溶解度低，这些化合物的生物利用度有限，限制了它们作为促进健康的药物的使用。本文描述了由于所提出的化合物生物利用度低而导致的局限性，并收集了旨在提高其生物利用度的方法。此外，这项工作还回顾了提供橙皮苷和橙皮素神经保护和抗糖尿病特性的研究证据，并详细研究了报道的作用机制在慢性疾病中的重要性。鉴于有充分文献记载的促进健康的活性，寻找克服生物利用度差问题的方法非常重要。
