[完整血液及烧伤犬血液中中分子量肽的神经营养作用机制研究]

[Study of mechanisms of neurotropic action of middle molecular weight peptides in the blood of intact blood and dogs with burns].

作者信息

Volchegorskiĭ I A, Val'dman B M, Puzhevskiĭ A S, Lifshits R I

出版信息

Patol Fiziol Eksp Ter. 1989 Jan-Feb(1):45-9.

Abstract

The authors studied the role of changes of lipid peroxidation and monoamine oxidase activity in the brain of mice under the effect of various fractions of middle-mass peptides (MMP) obtained from blood of intact dogs and dogs with burns. A marked neurotropic effect of MMP was manifested by changes of the behavior of rats in the "open field". The blood of dogs with burns was found to contain an MMP fraction whose neurotropic effect was caused by changes of the monoamine oxidase activity of the brain. The results bear evidence that the prooxidant action of MMP of blood of intact animals on brain tissue is associated with the neurotropic effect of these compounds. The data obtained is discussed from the standpoint of burn encephalopathy.

摘要

作者研究了从正常犬和烧伤犬血液中提取的中等分子量肽（MMP）各组分作用下，小鼠脑内脂质过氧化变化及单胺氧化酶活性的作用。MMP显著的神经趋向性作用通过大鼠在“旷场试验”中的行为变化得以体现。研究发现，烧伤犬血液中含有一种MMP组分，其神经趋向性作用是由脑内单胺氧化酶活性变化引起的。结果证明，正常动物血液中MMP对脑组织的促氧化作用与这些化合物的神经趋向性作用相关。从烧伤性脑病的角度对所获数据进行了讨论。

相似文献

1

[Study of mechanisms of neurotropic action of middle molecular weight peptides in the blood of intact blood and dogs with burns].[完整血液及烧伤犬血液中中分子量肽的神经营养作用机制研究]

Patol Fiziol Eksp Ter. 1989 Jan-Feb(1):45-9.

2

[Role of middle-molecule blood peptides in the development of cardiac depression in thermal burns].[中分子血液肽在热烧伤所致心脏抑制发展中的作用]

Biull Eksp Biol Med. 1986 Mar;101(3):280-2.

3

[Effect of middle molecular weight peptides, isolated from blood of intact dogs and those with burns, on proteolysis in mouse tissue].[从正常犬和烧伤犬血液中分离出的中分子量肽对小鼠组织蛋白水解的影响]

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[Effect of blood middle-molecule peptides from healthy dogs and dogs with burns on the permeability of the hemato-encephalic barrier].[健康犬与烧伤犬血液中分子肽对血脑屏障通透性的影响]

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Patol Fiziol Eksp Ter. 1992 Jan-Feb(1):31-5.

6

[Stress-modulating action of medium molecular weight peptides, isolated from blood of intact and burned animals].[从完整动物和烧伤动物血液中分离出的中分子量肽的应激调节作用]

Patol Fiziol Eksp Ter. 1993 May-Jun(3):22-6.

7

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Patol Fiziol Eksp Ter. 1985 Nov-Dec(6):39-42.

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