Volchegorskiĭ I A, Val'dman B M, Puzhevskiĭ A S, Lifshits R I
Patol Fiziol Eksp Ter. 1989 Jan-Feb(1):45-9.
The authors studied the role of changes of lipid peroxidation and monoamine oxidase activity in the brain of mice under the effect of various fractions of middle-mass peptides (MMP) obtained from blood of intact dogs and dogs with burns. A marked neurotropic effect of MMP was manifested by changes of the behavior of rats in the "open field". The blood of dogs with burns was found to contain an MMP fraction whose neurotropic effect was caused by changes of the monoamine oxidase activity of the brain. The results bear evidence that the prooxidant action of MMP of blood of intact animals on brain tissue is associated with the neurotropic effect of these compounds. The data obtained is discussed from the standpoint of burn encephalopathy.
作者研究了从正常犬和烧伤犬血液中提取的中等分子量肽（MMP）各组分作用下，小鼠脑内脂质过氧化变化及单胺氧化酶活性的作用。MMP显著的神经趋向性作用通过大鼠在“旷场试验”中的行为变化得以体现。研究发现，烧伤犬血液中含有一种MMP组分，其神经趋向性作用是由脑内单胺氧化酶活性变化引起的。结果证明，正常动物血液中MMP对脑组织的促氧化作用与这些化合物的神经趋向性作用相关。从烧伤性脑病的角度对所获数据进行了讨论。
