Volchegorskiĭ I A, Val'dman B M, Skobeleva N A, Lifshits R I, Zurochka A V
Patol Fiziol Eksp Ter. 1992 Jan-Feb(1):31-5.
Preliminary injection of middle mass peptides (MMP) obtained from blood of intact dogs and dogs with burn injury aggravated the response of mice and rats to thermal injury. The mortality among mice with burns grew and the reaction of the lymphoid organs (thymus and spleen) of rats to the thermal burn was intensified. The aggravating action of MMP in mice correlated well with their damaging effect in experiments on human blood neutrophils. A MMP fraction possessing a protecting effect in burns in rats was isolated from the blood of intact dogs. The data obtained are discussed from the standpoint of the pathogenetic importance of MMP in burn disease.
预先注射从健康犬和烧伤犬血液中获得的中间质量肽（MMP）会加重小鼠和大鼠对热损伤的反应。烧伤小鼠的死亡率增加，大鼠淋巴器官（胸腺和脾脏）对热烧伤的反应增强。MMP对小鼠的加重作用与其在人体血液中性粒细胞实验中的损伤作用密切相关。从健康犬血液中分离出一种在大鼠烧伤中具有保护作用的MMP组分。从烧伤疾病中MMP的发病机制重要性的角度对所得数据进行了讨论。
