Lifshits R I, Val'dman B M, Volchegorskiĭ I A, Puzhevskiĭ A S
Biull Eksp Biol Med. 1986 Mar;101(3):280-2.
Using ultrafiltration and subsequent gel filtration a fraction of middle mass peptides (MMP) possesing cardiodeppressing activity, has been isolated from the blood plasma of dogs exposed to burn injury. In contrast to the corresponding MMP fraction from healthy animal blood, this fraction suppressed contractility of the isolated rat's papillary muscle. Moreover, the active MMP fraction caused an appreciable bradycardia when administered subarachnoidally. The same phenomenon is typical of the corresponding MMP fraction from intact dog's blood, but the rate of bradycardia is significantly lower than that obtained for the fraction from the blood of injured animals. The possibility of local and central-mediated influence of the active fraction on heart functions is discussed. Central-mediated action of the active MMP fraction is confirmed by the ability of other MMP fractions from the blood of injured animals to enhance the blood-brain barrier permeability.
通过超滤和随后的凝胶过滤，从烧伤犬的血浆中分离出了具有心脏抑制活性的中等分子量肽（MMP）组分。与来自健康动物血液的相应MMP组分相比，该组分抑制了离体大鼠乳头肌的收缩性。此外，活性MMP组分蛛网膜下腔给药时会引起明显的心动过缓。完整犬血液中的相应MMP组分也有同样的现象，但心动过缓的速率明显低于受伤动物血液中的组分。文中讨论了活性组分对心脏功能的局部和中枢介导影响的可能性。受伤动物血液中其他MMP组分增强血脑屏障通透性的能力证实了活性MMP组分的中枢介导作用。
