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Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension.

作者信息

McNally E M, Buttrick P M, Leinwand L A

机构信息

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.

出版信息

Nucleic Acids Res. 1989 Apr 11;17(7):2753-67. doi: 10.1093/nar/17.7.2753.

DOI:10.1093/nar/17.7.2753
PMID:2717409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC317655/
Abstract

Cardiac myosin heavy chain (MHC) isoform distribution has been shown to undergo changes during development, in response to hormonal stimuli, and during pathologic states like hypertension. We initiated a study of myosin light chain 1 (MLC1) expression in cardiac tissue to determine whether MLC1 undergoes changes similar to those seen for MHC. We isolated a full length cDNA for the predominant MLC1 sequence in rat hearts. This gene is expressed in ventricular tissue at much higher levels than in atrial tissue. Based on its expression pattern and sequence homology, this cDNA encodes the rat ventricular MLC1 and has been named RVMLC1. RVMLC1 is expressed at very low levels in cardiac tissue during early development and is expressed abundantly after birth and in adult hearts. The expression of RVMLC1 was found not to change in the hearts of rats with renovascular hypertension.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/317655/9ce378649f60/nar00124-0389-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/317655/8e7b6124d8af/nar00124-0384-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/317655/96b25cfecf38/nar00124-0385-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/317655/bd0e8d2df68b/nar00124-0387-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/317655/121a8412da70/nar00124-0388-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/317655/9ce378649f60/nar00124-0389-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/317655/8e7b6124d8af/nar00124-0384-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/317655/96b25cfecf38/nar00124-0385-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/317655/bd0e8d2df68b/nar00124-0387-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/317655/121a8412da70/nar00124-0388-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8058/317655/9ce378649f60/nar00124-0389-a.jpg

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本文引用的文献

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Myosin from fetal hearts contains the skeletal muscle embryonic light chain.来自胎儿心脏的肌球蛋白含有骨骼肌胚胎轻链。
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肌球蛋白驱动的挽救家族性肥厚型心肌病相关突变肌钙蛋白 T 小鼠心脏的收缩储备和能量学是突变特异性的。
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Characterization of a rat myosin alkali light chain gene expressed in ventricular and slow twitch skeletal muscles.在心室肌和慢肌骨骼肌中表达的大鼠肌球蛋白碱性轻链基因的特性分析。
Nucleic Acids Res. 1989 Oct 11;17(19):7723-34. doi: 10.1093/nar/17.19.7723.
7
Complete cDNA sequence of rat atrial myosin light chain 1: patterns of expression during development and with hypertension.大鼠心房肌球蛋白轻链1的完整cDNA序列：发育过程中和高血压状态下的表达模式
Nucleic Acids Res. 1990 Mar 25;18(6):1581-6.
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Developmental regulation of myosin gene expression in mouse cardiac muscle.小鼠心肌中肌球蛋白基因表达的发育调控。
J Cell Biol. 1990 Dec;111(6 Pt 1):2427-36. doi: 10.1083/jcb.111.6.2427.
9
Myosin light chains and troponin C: structural and evolutionary relationships revealed by amino acid sequence comparisons.肌球蛋白轻链和肌钙蛋白C：通过氨基酸序列比较揭示的结构与进化关系
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10
Identification of sequences necessary for the association of cardiac myosin subunits.鉴定心肌肌球蛋白亚基缔合所需的序列。
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4
Alternative transcription and two modes of splicing results in two myosin light chains from one gene.可变转录和两种剪接模式导致一个基因产生两种肌球蛋白轻链。
Nature. 1984;308(5957):333-8. doi: 10.1038/308333a0.
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Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.心脏α和β肌球蛋白重链基因串联排列。
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Myosin isoenzyme changes in several models of rat cardiac hypertrophy.大鼠心肌肥大几种模型中的肌球蛋白同工酶变化。
Circ Res. 1981 Aug;49(2):525-32. doi: 10.1161/01.res.49.2.525.
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Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.心脏心室α和β肌球蛋白重链基因的表达受发育和激素调控。
J Biol Chem. 1984 May 25;259(10):6437-46.
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Isolation and characterization of human myosin heavy chain genes.人类肌球蛋白重链基因的分离与特性分析。
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3716-20. doi: 10.1073/pnas.80.12.3716.
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Molecular evidence for genetic exchanges among ribosomal genes on nonhomologous chromosomes in man and apes.人类和猿类非同源染色体上核糖体基因间发生基因交换的分子证据。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7323-7. doi: 10.1073/pnas.77.12.7323.
10
Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.用核酸外切酶III进行单向消化可为DNA测序创建靶向断点。
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