Iwasaki Kazuto, Maeda Kenta, Hidaka Kouki, Nemoto Kenji, Hirose Yoshitaka, Deguchi Shinji
Oral Health Prev Dent. 2016;14(3):207-14. doi: 10.3290/j.ohpd.a36099.
Heat-killed Lactobacillus plantarum L-137 (HK L-137) has been shown to activate innate and acquired immunity in humans. The aim of this randomised, double-blind, placebo-controlled clinical trial was to examine the effects of the oral administration of HK L-137 on the outcome of periodontal therapy.
Thirty-nine patients undergoing supportive periodontal therapy (SPT) were randomly assigned to receive a capsule containing 10 mg of HK L-137 or a placebo capsule daily for 12 weeks. Nineteen patients in the experimental group and 17 patients in the control group were followed-up. Clinical parameters, including plaque index (PI), gingival index (GI), bleeding on probing (BOP), and probing depth (PD) were scored at baseline and weeks 4, 8 and 12 prior to prophylaxis in conjunction with regular SPT visits.
BOP and the number of teeth or sites with PD ≥ 4 mm were significantly reduced in both groups by a successive SPT programme, while there was significantly greater PD reduction (p < 0.05) at teeth with site(s) with PD ≥ 4 mm at baseline in the experimental group than in the control group at week 12.
These clinical findings suggest that daily HK L-137 intake can decrease the depth of periodontal pockets in patients undergoing supportive periodontal therapy.
热灭活植物乳杆菌L-137（HK L-137）已被证明可激活人体的先天免疫和后天免疫。这项随机、双盲、安慰剂对照临床试验的目的是研究口服HK L-137对牙周治疗效果的影响。
39名接受支持性牙周治疗（SPT）的患者被随机分配，每天服用一粒含10毫克HK L-137的胶囊或一粒安慰剂胶囊，持续12周。对实验组的19名患者和对照组的17名患者进行随访。在基线以及与定期SPT就诊相结合的预防性治疗前的第4、8和12周，对包括菌斑指数（PI）、牙龈指数（GI）、探诊出血（BOP）和探诊深度（PD）在内的临床参数进行评分。
通过连续的SPT方案，两组的BOP以及PD≥4毫米的牙齿或部位数量均显著减少，而在第12周时，实验组中基线时PD≥4毫米的牙齿部位的PD减少幅度显著大于对照组（p<0.05）。
这些临床研究结果表明，每天摄入HK L-137可减少接受支持性牙周治疗患者的牙周袋深度。
