Steinmetz J E, Lavond D G, Thompson R F
Department of Psychology, Indiana University, Bloomington 47405.
Synapse. 1989;3(3):225-33. doi: 10.1002/syn.890030308.
Classical conditioning of skeletal muscle responses was accomplished by pairing microstimulation of the pontine nuclei as a conditioned stimulus (CS) with microstimulation of the dorsal accessory olive as an unconditioned stimulus (US). A conditioned response identical in form to the behavioral response elicited by the olivary stimulation was established when the CS was forward paired with the US, and behavioral extinction occurred with CS-alone presentations or unpaired CS-US presentations. Conditioned responding could not be established or maintained when the CS and US were simultaneously presented or when the US preceded the CS (i.e., backward paired). Complete lesions of the interpositus nucleus abolished both conditioned and unconditioned responses. These findings support the idea that plasticity associated with classical conditioning of skeletal muscle responses occurs in regions of the cerebellum that receive convergent CS and US input.
骨骼肌反应的经典条件反射是通过将脑桥核的微刺激作为条件刺激（CS）与背侧副橄榄核的微刺激作为非条件刺激（US）配对来实现的。当CS与US正向配对时，建立了一种形式与橄榄核刺激引发的行为反应相同的条件反应，并且在单独呈现CS或CS-US非配对呈现时出现行为消退。当CS和US同时呈现或US先于CS呈现（即反向配对）时，无法建立或维持条件反应。间位核的完全损伤消除了条件反应和非条件反应。这些发现支持这样一种观点，即与骨骼肌反应经典条件反射相关的可塑性发生在小脑接受汇聚的CS和US输入的区域。
