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家兔在经典性眼睑条件反射的习得、消退和逆向训练过程中小脑皮质和间位核活动的变化

Changes in rabbit cerebellar cortical and interpositus nucleus activity during acquisition, extinction, and backward classical eyelid conditioning.

作者信息

Gould T J, Steinmetz J E

机构信息

Department of Psychology, Indiana University, Bloomington 47405, USA.

出版信息

Neurobiol Learn Mem. 1996 Jan;65(1):17-34. doi: 10.1006/nlme.1996.0003.

DOI:10.1006/nlme.1996.0003
PMID:8673404
Abstract

Multiple- and single-unit neuronal activities were recorded from cerebellar cortex (Larsell's lobule HVI and adjacent ansiform cortex) and the cerebellar interpositus nucleus during forward (CS-US), backward (US-CS), and explicitly unpaired classical eyeblink conditioning in several rabbits. Whereas learning-related activity was observed in the interpositus nucleus only during forward pairing of the conditioning stimuli, a variety of patterns of learning-related neuronal firings were observed in cerebellar cortex during forward, backward, and even unpaired presentations of the conditioning stimuli. These data suggest that the cerebellar cortex and the deep cerebellar nuclei play different roles during classical eyeblink conditioning.

摘要

在几只兔子进行正向(条件刺激-非条件刺激)、反向(非条件刺激-条件刺激)以及明确不配对的经典眨眼条件反射过程中,记录了小脑皮质(拉塞尔小叶HVI及相邻的伞状皮质)和小脑间位核的多单位和单单位神经元活动。虽然仅在条件刺激的正向配对期间在间位核中观察到与学习相关的活动,但在条件刺激的正向、反向甚至不配对呈现期间,在小脑皮质中观察到了多种与学习相关的神经元放电模式。这些数据表明,在经典眨眼条件反射过程中,小脑皮质和小脑深部核团发挥着不同的作用。

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