Söltz-Szöts J, Schneider S, Niebauer B, Knobler R M, Lindmaier A
Ludwig Boltzmann-Institut zur Erforschung infektiöser venero-dermatolog. Erkrankungen, Wien.
Z Hautkr. 1989 Feb 15;64(2):129-31.
Erythromycin and josamycin are the antibiotics of choice in the treatment of pregnant women with Chlamydia infection. On the basis of differing recommendations in the literature regarding treatment period and dosage, two groups of pregnant women were treated with josamycin according to different dosage schedules: Group A: 170 patients treated with 2 x 500 mg daily for 12 days. Group B: 120 patients treated with 3 x 500 mg daily for 8 days. The diagnosis was confirmed by immunofluorescence with monoclonal antibodies. Non-responding patients were treated again with a similar dose. 17% of the patients in group A and 9.1% in group B were still positive for Chlamydia after the first course of treatment. After a second course, 13.6% of group A and none of group B showed positive controls. Failures of therapy after the first treatment course can be attributed to errors in dosage or re-infection, whereas failures after the second course must be due to bad compliance. Our results suggest that pregnant women with Chlamydia infection are most efficiently treated with high dosages of josamycin over a short period of time.
红霉素和交沙霉素是治疗衣原体感染孕妇的首选抗生素。基于文献中关于治疗疗程和剂量的不同建议，两组衣原体感染孕妇按不同剂量方案接受交沙霉素治疗：A组：170例患者，每日2次，每次500mg，治疗12天。B组：120例患者，每日3次，每次500mg，治疗8天。诊断通过单克隆抗体免疫荧光法确诊。无反应的患者再次给予相似剂量治疗。A组17%的患者和B组9.1%的患者在第一个疗程治疗后衣原体仍呈阳性。第二个疗程后，A组13.6%的患者衣原体呈阳性，而B组无一例阳性。第一个疗程治疗失败可能归因于剂量错误或再次感染，而第二个疗程后治疗失败必定是由于依从性差。我们的结果表明，衣原体感染孕妇短期内接受高剂量交沙霉素治疗效果最佳。
