Kozlova I A, Trubnikov V I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1989;89(1):68-73.
Investigated and genetically analyzed were inheritance variants in 225 families of probands with different forms of development of child schizophrenia and 519 blood relatives as well as in 1714 relatives of the 2nd and 3rd grades. Child schizophrenia as seen from the viewpoint of the monogenic model of inheritance with total or partial penetrance of the "major" gene proved inconsistent with the characteristics of family history and population distributions in the disease. The multifactorial model appeared the most adequate to describe the susceptibility system. In the framework of this model the correlation between the susceptibility components specific for a clinical form could be derived from distinguishing between genotypic and environmental components. The data indicate that in malignant and slow progredient schizophrenia the probands were genotypically similar to a greater extent that they were in paroxysmal-progredient form, as revealed by the inheritance coefficient of the former group (28-35%) which was lower than that of the latter group (64%).
对225个患有不同类型儿童精神分裂症的先证者家庭及其519名血亲以及1714名二级和三级亲属进行了遗传变异调查和基因分析。从具有“主要”基因完全或部分外显率的单基因遗传模型来看，儿童精神分裂症与该疾病的家族史和人群分布特征不一致。多因素模型似乎最适合描述易感性系统。在该模型框架下，临床形式特有的易感性成分之间的相关性可以通过区分基因型和环境成分得出。数据表明，在恶性和缓慢进展型精神分裂症中，先证者在基因型上的相似程度高于发作性进展型，前者组的遗传系数（28 - 35%）低于后者组（64%）。
