Koopman Peter, Sinclair Andrew, Lovell-Badge Robin
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
Murdoch Children's Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia.
Development. 2016 May 15;143(10):1633-7. doi: 10.1242/dev.137372.
On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV were abuzz with the story of a transgenic mouse in London called Randy. Why was this mouse so special? The mouse in question was a chromosomal female (XX) made male by the presence of a transgene containing the Y chromosome gene Sry This sex-reversal provided clear experimental proof that Sry was the elusive mammalian sex-determining gene. Twenty-five years on, we reflect on what this discovery meant for our understanding of how males and females arise and what remains to be understood.
1991年5月9日星期四，全世界醒来看到了生物研究取得突破的头版新闻。从华盛顿到卧龙岗，报纸、广播和电视都在热议一只名叫兰迪的伦敦转基因小鼠的故事。这只小鼠为何如此特别？这只小鼠是染色体雌性（XX），由于存在一个包含Y染色体基因Sry的转基因而变成了雄性。这种性别反转提供了明确的实验证据，证明Sry就是难以捉摸的哺乳动物性别决定基因。二十五年过去了，我们反思这一发现对我们理解雄性和雌性如何产生意味着什么，以及还有哪些有待理解的问题。
