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以原发性肾上腺皮质功能减退症反复肾上腺危象形式出现的格雷夫斯甲状腺毒症延迟诊断

Delayed Diagnosis of Graves' Thyrotoxicoisis Presenting as Recurrent Adrenal Crisis in Primary Adrenal Insufficiency.

作者信息

Naik Dukhabandhu, Jebasingh K Felix, Thomas Nihal

机构信息

Associate Professor, Department of Endocrinology, Diabetes and Metabolism, Christian Medical College , Vellore, Tamil Nadu, India .

Senior Registrar, Department of Endocrinology, Diabetes and Metabolism, Christian Medical College , Vellore, Tamil Nadu, India .

出版信息

J Clin Diagn Res. 2016 Apr;10(4):OD20-2. doi: 10.7860/JCDR/2016/16395.7678. Epub 2016 Apr 1.

Abstract

Adrenal crisis is a potential life threatening complication. The common causes of adrenal crisis are infections, surgical stress and abrupt cessation of steroid medications. Endocrine causes like Graves' disease with thyrotoxicosis is one of the less common causes of an adrenal crisis. We report a 42-year-old female who presented with recurrent episodes of adrenal crisis due to delayed diagnosis of thyrotoxicosis. She was initially treated with Carbimazole followed by Radio-iodine ablation and currently she is euthyroid. Her adrenal insufficiency was initially treated with hydrocortisone during the time of adrenal crisis followed by Prednisolone 5 mg once daily in the morning along with fludrocortisone 50 mcg once daily. This case highlights the need for high index of suspicion and less common causes like thyrotoxicosis should be ruled out in patients with adrenal crisis.

摘要

肾上腺危象是一种潜在的危及生命的并发症。肾上腺危象的常见病因包括感染、手术应激和类固醇药物的突然停用。像伴有甲状腺毒症的格雷夫斯病这样的内分泌病因是肾上腺危象较不常见的病因之一。我们报告一名42岁女性,因甲状腺毒症诊断延迟而反复出现肾上腺危象发作。她最初接受甲巯咪唑治疗,随后进行放射性碘消融,目前甲状腺功能正常。她的肾上腺功能不全在肾上腺危象期间最初用氢化可的松治疗,随后每天早晨服用5毫克泼尼松龙以及每天服用50微克氟氢可的松。该病例强调了高度怀疑的必要性,对于肾上腺危象患者应排除像甲状腺毒症这样较不常见的病因。

相似文献

本文引用的文献

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Adrenal insufficiency.肾上腺功能不全。
Lancet. 2014 Jun 21;383(9935):2152-67. doi: 10.1016/S0140-6736(13)61684-0. Epub 2014 Feb 4.
9
Predisposing factors for adrenal insufficiency.肾上腺功能不全的诱发因素。
N Engl J Med. 2009 May 28;360(22):2328-39. doi: 10.1056/NEJMra0804635.

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