格雷夫斯病伴发肾上腺功能衰竭所致危及生命的高钙血症：一例报告并文献复习
Life-Threatening Hypercalcemia due to Graves' Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature.
作者信息
Ozkaya Hande Mefkure, Keskin Fatma Ela, Haliloglu Ozlem Asmaz, Senel Tugba Elif, Kadioglu Pinar
机构信息
Endocrinology and Metabolism, Cerrahpasa Medical School, University of Istanbul, 34098 Istanbul, Turkey.
出版信息
Case Rep Endocrinol. 2015;2015:684648. doi: 10.1155/2015/684648. Epub 2015 Mar 24.
Abstract
A 47-year-old woman presented with the complaints of nausea, vomiting, and weight loss. She had a history of bilateral surrenalectomy due to Cushing's syndrome. On examination she had tachycardia and orthostatic hypotension. Laboratory examinations revealed hypercalcemia and suppressed parathyroid hormone levels. She also had thyrotoxicosis due to Graves' disease. The investigations to rule out a malignancy were negative. With steroid, zoledronic acid, and antithyroid drug treatment her symptoms were resolved and calcium level was normalized. This case highlights the importance of recognizing thyrotoxicosis and concomitant adrenal failure as a possible cause of severe hypercalcemia.
摘要
一名47岁女性因恶心、呕吐和体重减轻前来就诊。她有因库欣综合征行双侧肾上腺切除术的病史。检查发现她有心动过速和体位性低血压。实验室检查显示高钙血症和甲状旁腺激素水平受抑制。她还患有格雷夫斯病导致的甲状腺毒症。排除恶性肿瘤的检查结果为阴性。经过类固醇、唑来膦酸和抗甲状腺药物治疗，她的症状得到缓解，血钙水平恢复正常。该病例强调了认识到甲状腺毒症和并发肾上腺功能衰竭作为严重高钙血症可能病因的重要性。
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