Eshete Eskedar Awelachew, Weldemariam Tewabech Zewde
Ethiop Med J. 2016 Jan;54(1):21-5.
Physiological range of clinically important hematological laboratory values and lipid profiles of healthy population in Ethiopia is not well assessed.
to determine hematologic and lipid profiles of healthy blood donors in Addis Ababa.
Red Cross Society located in Addis Ababa was selected as a study area. 336 donors; age range between 18-58 years participated. Venous blood sample was collected by tube containing Ehtylenediaminetetraaceticacid tri potassium (EDTA) for hematology test and sterile tube for lipid test. After centrifugation serum was extracted for lipid test and transported to St. Pauls's Millennium Medical College (SPHMMC) within 5-8hrs of sample collection. IBM.SPSS version 21 was used for data analysis, statistical significance was set at P< 0.05 and 95% CL was accepted.
Red blood cell count, mean corpuscular volume, platelet count and triglyceride level were significantly higher in the present study than the reference range. RBC indices, white blood cell, Hemoglobin, hematocrit, high density lipoprotein, low density lipoprotein and total cholesterol were higher in the reference range used in clinical practice. Significantly higher red blood count (p = 0.000), Hg (p = 0.000), Hematocrit (p = 0.000) and mean corpuscular hemoglobin concentration (p = 0.009) were observed in the male. Significantly higher platelet count and high density lipoprotein were observed among females (p = 0.001 and p = 0.001 respectively). No significant change in hematological laboratory values and lipid profiles was seen across age groups.
It is evident from this study that hematological and lipid variables obtained were statistically significantly different from the reference range currently used in clinical practice.
埃塞俄比亚健康人群临床重要血液学实验室值和血脂谱的生理范围尚未得到充分评估。
确定亚的斯亚贝巴健康献血者的血液学和血脂谱。
选择位于亚的斯亚贝巴的红十字会作为研究区域。336名年龄在18至58岁之间的献血者参与。通过含有乙二胺四乙酸三钾（EDTA）的试管采集静脉血样用于血液学检测，通过无菌试管采集用于血脂检测。离心后提取血清用于血脂检测，并在样本采集后5至8小时内送至圣保罗千年医学院（SPHMMC）。使用IBM.SPSS 21版进行数据分析，设定统计学显著性为P<0.05，并接受95%置信区间。
本研究中红细胞计数、平均红细胞体积、血小板计数和甘油三酯水平显著高于参考范围。临床实践中使用的参考范围内红细胞指数、白细胞、血红蛋白、血细胞比容、高密度脂蛋白、低密度脂蛋白和总胆固醇较高。男性的红细胞计数（p = 0.000）、血红蛋白（p = 0.000）、血细胞比容（p = 0.000）和平均红细胞血红蛋白浓度（p = 0.009）显著更高。女性的血小板计数和高密度脂蛋白显著更高（分别为p = 0.001和p = 0.001）。各年龄组的血液学实验室值和血脂谱无显著变化。
从本研究可以明显看出，所获得的血液学和血脂变量与目前临床实践中使用的参考范围在统计学上有显著差异。
