Dil Chora Hospital, Dire Dawa, Ethiopia.
Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
PLoS One. 2021 Feb 16;16(2):e0244314. doi: 10.1371/journal.pone.0244314. eCollection 2021.
Reference interval (RI) for hematological parameters is used to interpret laboratory test results in the diagnosis, management and monitoring of hematologic disorders. Several factors including sex, age, dietary patterns, pregnancy status, ethnicity and geographic location affect hematological RIs. However, manufacturers derived reference value is currently in use in most developing countries including Ethiopia. This study aimed to establish hematological RIs for adult population living in Dire Dawa town, East Ethiopia.
In this cross-sectional study, 513 apparently healthy adults of Dire Dawa town were enrolled from January to March 2019. From these, 342 (171 males and 171 non-pregnant females) were aged 18-65 years while 171 were pregnant women aged 15-49 years. After obtaining written informed consent, 5ml fresh whole blood was collected of which 2ml was used for hematologic analysis using Mindray BC-3000plus hematology analyzer and 3ml for serological tests. The 2.5th and 97.5th RI was computed by non-parametric test employing SPSS version 24. P-value <0.05 was considered statistically significant.
Males had significantly higher reference value for most of red cell parameters (Hgb, RBC, HCT, MCH and MCHC) than females (p <0.05), while most of the WBC parameters were significantly higher in females than males. Moreover, non-pregnant women had higher values for most of red cell parameters than pregnant women. Pregnant women had higher WBC parameters than their non-pregnant counterparts.
The hematologic RIs obtained in this study shows variation between genders, between pregnant and non-pregnant women, from the clinical practice currently utilised in Dire Dawa town and from studies conducted in Ethiopia, African countries as well as the Western population. It underscores the need for utilising gender and pregnancy specific, locally derived hematologic RI for better management, diagnosis and monitoring of hematologic disorders for adults of both genders and pregnant women.
参考区间（RI）用于解释血液学参数的实验室检测结果，以帮助诊断、管理和监测血液系统疾病。包括性别、年龄、饮食模式、妊娠状态、种族和地理位置在内的多种因素会影响血液学 RI。然而，目前包括埃塞俄比亚在内的大多数发展中国家仍在使用制造商提供的参考值。本研究旨在为居住在埃塞俄比亚东部城市迪雷达瓦的成年人群建立血液学 RI。
本横断面研究于 2019 年 1 月至 3 月期间纳入了 513 名来自迪雷达瓦镇的健康成年人。其中 342 名（171 名男性和 171 名非妊娠女性）年龄在 18-65 岁之间，171 名妊娠女性年龄在 15-49 岁之间。在获得书面知情同意后，采集 5ml 新鲜全血，其中 2ml 用于使用 Mindray BC-3000plus 血液分析仪进行血液学分析，3ml 用于血清学检测。采用非参数检验，使用 SPSS 版本 24 计算第 2.5 百分位数和第 97.5 百分位数。P 值<0.05 被认为具有统计学意义。
与女性相比，男性的大多数红细胞参数（Hgb、RBC、HCT、MCH 和 MCHC）的参考值显著更高（p<0.05），而女性的大多数白细胞参数显著高于男性。此外，非妊娠女性的大多数红细胞参数值高于妊娠女性。与非妊娠女性相比，妊娠女性的白细胞参数更高。
本研究获得的血液学 RI 在性别、妊娠与非妊娠女性、迪雷达瓦镇当前临床实践以及埃塞俄比亚、非洲国家以及西方人群的研究中均存在差异。这突出表明，需要针对两性和妊娠女性，利用当地获取的特定血液学 RI，以便更好地管理、诊断和监测血液系统疾病。
Zotero 插件