Jabir Nasimudeen R, Firoz Chelapram K, Bhushan Ashish, Tabrez Shams, Kamal Mohammad A
King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia.
Department of Health and Biomedical Sciences, Symbiosis International University, Pune 412115, India.
Anticancer Agents Med Chem. 2018;18(1):6-14. doi: 10.2174/1871520616666160520112839.
BACKGROUND & OBJECTIVE: Cancer is one of the leading causes of death worldwide. In view of ever increasing number associated with cancer related death, there is an urgent need to find out a novel compound especially of natural origin (better efficacy, less or non-toxic and cost effective) that could serve against the treatment of all forms of cancer. Currently, available treatment options related to cancer have their certain limitations especially in the case of solid tumors.
In search of the natural anticancer compound, alkaloids, in general, have been exploited by the scientist working in this field of research. Among these alkaloids, azoles (secondary metabolite) have been significantly highlighted in literature because of their anticancer potential and better efficacy against various forms of cancer.
Their mechanism of action includes induction in the cleavage of poly-ADP ribose polymerase (PARP), induction of caspase 3 and caspase 9, modulation of nuclear factor kappa B, damage to DNA, cell cycle arrest at G1 and G2/M stage, apoptosis and c-Myb inhibition. In the current article, we have tried to cover various azoles especially from oxazoles, thiazoles and carbazoles class that have been reported for their anticancer potential.
Based on our article, we believe that, soon, the scientific community will come up with certain azole which will work against cancer at large rather than a specific type of cancer.
癌症是全球主要死因之一。鉴于与癌症相关的死亡人数不断增加，迫切需要找到一种新型化合物，尤其是天然来源的（疗效更好、毒性更小或无毒且成本效益高），可用于治疗所有类型的癌症。目前，现有的癌症治疗选择存在一定局限性，尤其是在实体瘤方面。
为寻找天然抗癌化合物，该研究领域的科学家们普遍对生物碱进行了探索。在这些生物碱中，唑类（次生代谢产物）因其抗癌潜力和对各种癌症的较好疗效而在文献中受到显著关注。
它们的作用机制包括诱导多聚ADP核糖聚合酶（PARP）裂解、诱导半胱天冬酶3和半胱天冬酶9、调节核因子κB、损伤DNA、使细胞周期停滞在G1期和G2/M期、诱导凋亡以及抑制c-Myb。在本文中，我们试图涵盖各种唑类，特别是恶唑类、噻唑类和咔唑类中已报道具有抗癌潜力的化合物。
基于我们的文章，我们相信，不久之后，科学界将找到某种能广泛对抗癌症而非特定类型癌症的唑类化合物。
