Department of Pharmacy, School of Medical & Allied Sciences, GD Goenka University, Gurugram, India.
Department of Pharmaceutical Sciences, MD University, Rohtak, India.
Anticancer Agents Med Chem. 2021;21(15):1957-1976. doi: 10.2174/1871520621666210112112422.
Despite significant advancement in oncology research, cancer still poses one of the leading causes of mortality worldwide. The increased incidences of cancer may be attributed to the limited efficacy and disastrous side effects of conventional therapies like chemotherapy, radiotherapy and surgery. Azole containing medicinal agents are known for plethora of medicinal properties, including anticancer potential.
In this review, we highlighted azole containing natural products with anticancer potential from marine sources.
A comprehensive literature search was performed for writing the review. Updated views about various marine sponges, cyanobacteria, tunicates and microalgae producing azole nucleus containing secondary metabolites with anticancer potential have been discussed.
The present article describes the structural, chemical, and biological features of azoles containing natural agents from marine sources with promising anti-cancer potential. Additionally, current challenges and future perspectives of azoles in cancer prevention and treatment are also discussed.
This review might encourage scientific community to explore marine sources for developing novel and potent azole containing anti-cancer agents with better safety profile.
尽管肿瘤学研究取得了重大进展，但癌症仍然是全球主要死亡原因之一。癌症发病率的增加可能归因于化疗、放疗和手术等传统疗法疗效有限且副作用严重。含唑类药物因其具有多种药用特性而闻名，包括抗癌潜力。
在这篇综述中，我们强调了具有抗癌潜力的含唑天然产物来自海洋来源。
为撰写这篇综述进行了全面的文献检索。讨论了具有抗癌潜力的含唑核的各种海洋海绵、蓝藻、被囊动物和微藻产生的次生代谢物的结构、化学和生物学特征。
本文描述了具有潜在抗癌作用的含唑天然产物的结构、化学和生物学特性。此外，还讨论了唑类化合物在癌症预防和治疗方面的当前挑战和未来展望。
本综述可能鼓励科学界探索海洋资源，开发具有更好安全性的新型强效含唑抗癌药物。
