Chan Lester Wai Mon, Imanishi Jungo, Ngan Samuel Y, Chander Sarat, Chu Julie, Thorson Renae, Pang Grant, Choong Peter
Department of Orthopaedics, St. Vincent's Hospital, Melbourne, VIC 3065, Australia; Department of Orthopaedic Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433.
Department of Orthopaedics, St. Vincent's Hospital, Melbourne, VIC 3065, Australia.
Sarcoma. 2016;2016:2549616. doi: 10.1155/2016/2549616. Epub 2016 Apr 20.
We report the early results of nine patients with periacetabular malignancies treated with Enneking and Dunham type 2 resection and reconstruction using extracorporeally irradiated (ECI) tumour bone combined with total hip arthroplasty (THA). Diagnosis was chondrosarcoma in six patients, osteosarcoma in two patients, and metastatic renal cell carcinoma in one patient. All patients underwent surgical resection and the resected specimen was irradiated with 50 Gy in a single fraction before being prepared for reimplantation as a composite autograft. The mean follow-up was 21 months (range, 3-59). All patients were alive at latest follow-up. No local recurrence was observed. One patient serially developed three pulmonary metastases, all of which were resected. One experienced hip dislocation due to incorrect seating of an acetabular liner. This was successfully treated with revision of the liner with no further episodes of instability. There were no cases of deep infection or loss of graft. The average Musculoskeletal Tumor Society (MSTS) score was 75% (range, 57-87%). Type 2 pelvic reconstruction with ECI and THA has shown excellent early oncological and functional results in our series. Preservation of the gluteus maximus and hip abductors is important for joint stability and prevention of infection.
我们报告了9例髋臼周围恶性肿瘤患者采用Enneking和Dunham 2型切除术及重建术的早期结果,该重建术使用体外照射(ECI)肿瘤骨联合全髋关节置换术(THA)。6例患者诊断为软骨肉瘤,2例为骨肉瘤,1例为转移性肾细胞癌。所有患者均接受了手术切除,切除标本在单次分割照射50 Gy后,准备作为复合自体移植物重新植入。平均随访时间为21个月(范围3 - 59个月)。在最近一次随访时所有患者均存活。未观察到局部复发。1例患者先后出现3次肺转移,均接受了切除。1例因髋臼内衬放置不当出现髋关节脱位,通过更换内衬成功治疗,未再出现不稳定情况。无深部感染或移植物丢失病例。肌肉骨骼肿瘤学会(MSTS)平均评分为75%(范围57 - 87%)。在我们的系列研究中,采用ECI和THA的2型骨盆重建术显示出优异的早期肿瘤学和功能结果。保留臀大肌和髋外展肌对关节稳定性和预防感染很重要。