Kathol R G, Anton R, Noyes R, Gehris T
Department of Psychiatry, University of Iowa Hospitals, Iowa City 52242.
Biol Psychiatry. 1989 Apr 1;25(7):873-8. doi: 10.1016/0006-3223(89)90267-9.
Urinary free cortisol (UFC) excretion in 31 patients with major depression is directly compared to UFC levels in 65 patients with panic disorder and 36 controls. Patients with depression demonstrated significantly higher UFC excretion [43 +/- 37 micrograms/g creatinine (cr)] than patients with panic disorder (29 +/- 13 micrograms/g-cr) or controls (22 +/- 10 micrograms/g-cr) (F = 8.5, df = 129, p less than 0.001). Panic patients with a secondary depression (35 +/- 17 micrograms/g-cr) or those with agoraphobia (34 +/- 14 micrograms/g-cr) had UFC levels that were in-between patients with primary major depression and panic patients without these complications (25 +/- 11 micrograms/g-cr). These findings support the hypothesis that patients with major depression, whether primary or secondary, and those with agoraphobia excrete more UFC than patients with uncomplicated panic disorder. This occurs despite the fact that panic disorder might also be expected to raise the stress-responsive hormone cortisol.
对31例重度抑郁症患者的尿游离皮质醇（UFC）排泄量与65例惊恐障碍患者及36例对照者的UFC水平进行了直接比较。抑郁症患者的UFC排泄量[43±37微克/克肌酐（cr）]显著高于惊恐障碍患者（29±13微克/克 - cr）或对照者（22±10微克/克 - cr）（F = 8.5，自由度 = 129，p＜0.001）。伴有继发性抑郁症的惊恐患者（35±17微克/克 - cr）或患有广场恐惧症的患者（34±14微克/克 - cr）的UFC水平介于原发性重度抑郁症患者和无这些并发症的惊恐患者（25±11微克/克 - cr）之间。这些发现支持了这样一种假设，即无论是原发性还是继发性重度抑郁症患者以及患有广场恐惧症的患者，其UFC排泄量均高于无并发症的惊恐障碍患者。尽管惊恐障碍也可能会使应激反应激素皮质醇升高，但仍出现了这种情况。
