Karimi Jashni Hojatollah, Kargar Jahromi Hossein, Ghorbani Ranjbary Ali, Kargar Jahromi Zahra, Khabbaz Kherameh Zahra
Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
Young Researchers and Elite Club, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
Int J Reprod Biomed. 2016 Feb;14(2):75-80.
Asparagus is a plant with high nutritional, pharmaceutical, and industrial values.
The present study aimed to evaluate the effect of aqueous extract of asparagus roots on the hypothalamic-pituitary-gonadal axis hormones and oogenesis in female rats.
In this experimental study, 40 adult female Wistar rats were divided into five groups, which consist 8 rats. Groups included control, sham and three experimental groups receiving different doses (100, 200, 400 mg/kg/bw) of aqueous extract of asparagus roots. All dosages were administered orally for 28 days. Blood samples were taken from rats to evaluate serum levels of Gonadotropin releasing hormone (GnRH), follicular stimulating hormone (FSH), Luteinal hormone (LH), estrogen, and progesterone hormones. The ovaries were removed, weighted, sectioned, and studied by light microscope.
Dose-dependent aqueous extract of asparagus roots significantly increased serum levels of GnRH, FSH, LH, estrogen, and progestin hormones compared to control and sham groups. Increase in number of ovarian follicles and corpus luteum in groups treated with asparagus root extract was also observed (p<0.05).
Asparagus roots extract stimulates secretion of hypothalamic- pituitary- gonadal axis hormones. This also positively affects oogenesis in female rats.
芦笋是一种具有高营养、药用和工业价值的植物。
本研究旨在评估芦笋根水提取物对雌性大鼠下丘脑 - 垂体 - 性腺轴激素及卵子发生的影响。
在本实验研究中，40只成年雌性Wistar大鼠被分为五组，每组8只。分组包括对照组、假手术组和三个实验组，分别给予不同剂量（100、200、400毫克/千克/体重）的芦笋根水提取物。所有剂量均经口给药28天。采集大鼠血液样本以评估血清中促性腺激素释放激素（GnRH）、促卵泡激素（FSH）、黄体生成素（LH）、雌激素和孕激素的水平。取出卵巢，称重，切片，并通过光学显微镜进行研究。
与对照组和假手术组相比，芦笋根水提取物呈剂量依赖性地显著提高了血清中GnRH、FSH、LH、雌激素和孕激素的水平。在用芦笋根提取物处理的组中还观察到卵巢卵泡和黄体数量增加（p<0.05）。
芦笋根提取物刺激下丘脑 - 垂体 - 性腺轴激素的分泌。这也对雌性大鼠的卵子发生产生积极影响。
