Sepulveda N G, Wikswo J P
Biophys J. 1987 Apr;51(4):557-68. doi: 10.1016/S0006-3495(87)83381-7.
Cardiac tissue can be considered macroscopically as a bidomain, anisotropic conductor in which simple depolarization wavefronts produce complex current distributions. Since such distributions may be difficult to measure using electrical techniques, we have developed a mathematical model to determine the feasibility of magnetic localization of these currents. By applying the finite element method to an idealized two-dimensional bisyncytium with anisotropic conductivities, we have calculated the intracellular and extracellular potentials, the current distributions, and the magnetic fields for a circular depolarization wavefront. The calculated magnetic field 1 mm from the tissue is well within the sensitivity of a SQUID magnetometer. Our results show that complex bisyncytial current patterns can be studied magnetically, and these studies should provide valuable insight regarding the electrical anisotropy of cardiac tissue.
心脏组织在宏观上可被视为一个双区域、各向异性的导体，其中简单的去极化波前会产生复杂的电流分布。由于使用电学技术测量这种分布可能很困难，我们开发了一个数学模型来确定这些电流磁定位的可行性。通过将有限元方法应用于具有各向异性电导率的理想化二维双合胞体，我们计算了圆形去极化波前的细胞内和细胞外电位、电流分布以及磁场。距组织1毫米处计算出的磁场完全在超导量子干涉装置磁力计的灵敏度范围内。我们的结果表明，可以通过磁性研究复杂的双合胞体电流模式，这些研究应该能为心脏组织的电各向异性提供有价值的见解。
