Sepulveda N G, Wikswo J P
Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235.
J Cardiovasc Electrophysiol. 1994 Mar;5(3):258-67. doi: 10.1111/j.1540-8167.1994.tb01162.x.
One of the fundamental electrophysiologic problems that has not yet been completely elucidated is the response of cardiac tissue to externally applied electric currents. A limited number of theoretical and experimental techniques has been used to study the electric behavior of cardiac tissue in the presence of stimulating currents, and to demonstrate that the anisotropy in the passive electrical properties of the tissue plays an important role in the genesis and propagation of the activation wavefront and the resulting potential distributions.
In this work we have applied the finite element method to study the electric and magnetic fields produced by cardiac tissue in response to bipolar current injection, using a linear bidomain model to represent the tissue. We found that the transmembrane potential distribution close to the stimulus electrode has a rather complex geometrical pattern, with adjacent hyperpolarized and depolarized regions.
This behavior is consistent with previous theoretical and experimental results and may have implications in the study of electrical stimulation of cardiac tissue that are not apparent using other models.
尚未完全阐明的基本电生理问题之一是心脏组织对外加电流的反应。已使用有限的理论和实验技术来研究存在刺激电流时心脏组织的电行为，并证明组织被动电特性中的各向异性在激活波前的产生和传播以及由此产生的电位分布中起重要作用。
在这项工作中，我们应用有限元方法，使用线性双域模型来表示组织，研究心脏组织在双极电流注入时产生的电场和磁场。我们发现靠近刺激电极的跨膜电位分布具有相当复杂的几何图案，存在相邻的超极化和去极化区域。
这种行为与先前的理论和实验结果一致，可能对心脏组织电刺激的研究有影响，而使用其他模型时并不明显。
