Maĭsov N I, Gankina E M, Gol'dina O A, Mansil'ia V A, Koloskov Iu B
Biull Eksp Biol Med. 1989 Apr;107(4):399-402.
The content of some biogenic monoamines and their metabolites in rat brain and heart in different periods of oxygen epilepsia was studied using high performance liquid chromatography with electrochemical detection. It was shown that already at the 5th minute of exposure to oxygen adrenaline, DOPA and some noradrenaline metabolites disappeared in the brain and noradrenaline level reduced. At this period in rat heart the reduction of catecholamine content was the most distinct and serotonin level was unchanged. At the beginning of convulsive period the modifications of biogenic amines content were nonparallel in brain regions: in the heart the reduction of catecholamine level went on, especially in right ventricle. In the terminal phase of oxygen epilepsia brain biogenic amines increased, however, not up to normal meaning, heart catecholamines at this period were at the same level as at the beginning of the convulsive period.
采用高效液相色谱电化学检测法，研究了大鼠在不同氧性癫痫发作期脑和心脏中一些生物源性单胺及其代谢产物的含量。结果表明，在暴露于氧气的第5分钟，大脑中的肾上腺素、多巴和一些去甲肾上腺素代谢产物就已消失，去甲肾上腺素水平降低。在此期间，大鼠心脏中儿茶酚胺含量的降低最为明显，而血清素水平未发生变化。在惊厥期开始时，大脑不同区域生物源性胺含量的变化并不平行：心脏中儿茶酚胺水平持续降低，尤其是右心室。在氧性癫痫发作的末期，大脑生物源性胺有所增加，但未恢复到正常水平，此时心脏中的儿茶酚胺水平与惊厥期开始时相同。
