Gorozhanin V S, Galimov S D
Genetika. 1982 Dec;18(12):1953-9.
The results of the studies devoted to defining the content of biogenic monoamines and their metabolites in different parts of cerebrum in rats of two inbred Vistar and Krushinsky--Molodkina lines are presented. It is proved that the intact rats of Krushinsky--Molodkina line differ from Vistar rats in the higher contents of adrenaline and dopamine of the hypothalamus and striatum, of serotonin in the hypothalamus. Also, the tendency to lowering noradrenaline in the hypothalamus and striatum, as well as the higher activity of the pathways of oxidative desamination and O-methylation in the hypothalamus was shown. The pronounced shift in the level of monoamines and its metabolism has been observed under the influence of immobilization in Vistar rats. At the same time, none of the neurochemical parameters are altered in the rats of Krushinsky--Molodkina line. The results obtained are regarded from the point of view of genetically determined balance of activating and inactivating influence differing in various lines.
本文展示了关于确定两个近交系大鼠（Vistar系和Krushinsky-Molodkina系）大脑不同部位生物源性单胺及其代谢产物含量的研究结果。结果表明，Krushinsky-Molodkina系的正常大鼠与Vistar系大鼠不同，其下丘脑和纹状体中的肾上腺素和多巴胺含量较高，下丘脑中的血清素含量也较高。此外，还显示出下丘脑和纹状体中去甲肾上腺素降低的趋势，以及下丘脑氧化脱氨和O-甲基化途径的活性较高。在Vistar系大鼠中，固定应激的影响下观察到单胺水平及其代谢有明显变化。同时，Krushinsky-Molodkina系大鼠的神经化学参数均未改变。从不同品系中激活和失活影响的遗传决定平衡的角度来看待所获得的结果。
