Phillips A, Wainberg M A, Coates R, Klein M, Rachlis A, Read S, Shepherd F, Vellend H, Walmsley S, Halloran P
Department of Medicine, University of Toronto, Ont.
CMAJ. 1989 Jun 15;140(12):1456-60.
Eight patients with AIDS (acquired immune deficiency syndrome) but free of life-threatening infection were treated with the immunosuppressive drug cyclosporine for a mean of 53.9 days. The serum cyclosporine levels were maintained in the desired therapeutic range. All eight patients experienced severe toxic symptoms, which necessitated discontinuation of cyclosporine therapy in six. The serum levels of creatinine, urea and potassium rose during treatment and fell after therapy was stopped. The total leukocyte count, hemoglobin level, platelet count, total T-cell count, and T4- and T8-cell counts all fell markedly during treatment. The total leukocyte count, platelet count, and T4- and T8-cell counts rose after therapy was stopped, but the hemoglobin level remained low. No patient experienced resolution of symptoms during therapy, and the condition of all patients improved after treatment was stopped. The results of this pilot study indicate that cyclosporine does not alleviate, and may worsen, the symptoms and laboratory findings in patients with AIDS.
8名患获得性免疫缺陷综合征（艾滋病）但无危及生命感染的患者接受了免疫抑制药物环孢素治疗，平均治疗时间为53.9天。血清环孢素水平维持在理想的治疗范围内。所有8名患者均出现严重的毒性症状，其中6名患者因此必须停止环孢素治疗。治疗期间，肌酐、尿素和钾的血清水平升高，治疗停止后下降。治疗期间，白细胞总数、血红蛋白水平、血小板计数、总T细胞计数以及T4和T8细胞计数均显著下降。治疗停止后，白细胞总数、血小板计数以及T4和T8细胞计数有所上升，但血红蛋白水平仍较低。治疗期间没有患者症状缓解，治疗停止后所有患者的病情均有改善。这项初步研究的结果表明，环孢素不能缓解艾滋病患者的症状和实验室检查结果，甚至可能使其恶化。
