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利巴韦林可抑制人成年T淋巴细胞培养物中与淋巴结病相关病毒的复制。

Ribavirin suppresses replication of lymphadenopathy-associated virus in cultures of human adult T lymphocytes.

作者信息

McCormick J B, Getchell J P, Mitchell S W, Hicks D R

出版信息

Lancet. 1984 Dec 15;2(8416):1367-9. doi: 10.1016/s0140-6736(84)92060-9.

DOI:10.1016/s0140-6736(84)92060-9
PMID:6150368
Abstract

The in-vitro effect of ribavirin on the replication of lymphadenopathy-associated virus (LAV), one of the prototype viruses aetiologically associated with lymphadenopathy syndrome and acquired immunodeficiency syndrome, was tested. Ribavirin, a nucleoside, suppressed the replication of LAV in cultures of human adult T lymphocytes. Suppression occurred at ribavirin concentrations of 50 micrograms/ml or higher.

摘要

对利巴韦林在体外对淋巴结病相关病毒（LAV）复制的作用进行了检测，LAV是一种在病因学上与淋巴结病综合征和获得性免疫缺陷综合征相关的原型病毒。利巴韦林，一种核苷，在人类成人T淋巴细胞培养物中抑制了LAV的复制。在利巴韦林浓度为50微克/毫升或更高时出现抑制作用。

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