Ishibashi S, Yamada N, Shimano H, Takaku F, Akanuma Y, Murase T
3rd Department of Internal Medicine, University of Tokyo, Japan.
Clin Chem. 1989 May;35(5):808-12.
We studied the characteristics of very-low-density lipoproteins (VLDLs) composition in patients with non-insulin-dependent diabetes mellitus. VLDLs were isolated from 28 diabetics and 33 nondiabetics with a wide range of plasma lipid concentrations, so we could compare VLDL composition between the two groups at similar lipid concentrations. The mean cholesterol and triglyceride concentrations in plasma of diabetic subjects were 2170 (SD 570) and 2510 (SD 2230) mg/L, respectively, and 2230 (SD 560) and 2210 (SD 1830) mg/L in nondiabetics. Diabetic subjects showed positive correlations between plasma triglyceride concentrations and either preprandial blood glucose or glycated hemoglobin values (P less than 0.02 and less than 0.01, respectively). Concentrations of triglycerides, cholesterol, and apolipoproteins (apo) B, CII, CIII, and E in VLDL were not significantly different between diabetics and nondiabetics. At comparable triglyceride concentrations, the chemical compositions of the VLDL in the two groups were still very similar. Dividing the concentration of each component by the VLDL-apo B concentrations yielded similar contents of each component per unit of VLDL for the two groups. We conclude that the composition of VLDLs in diabetics is much the same as that in nondiabetics at comparable concentrations of triglycerides in plasma.
我们研究了非胰岛素依赖型糖尿病患者极低密度脂蛋白（VLDL）的组成特征。从28名糖尿病患者和33名非糖尿病患者中分离出VLDL，这些患者的血浆脂质浓度范围很广，因此我们可以在相似脂质浓度下比较两组的VLDL组成。糖尿病受试者血浆中胆固醇和甘油三酯的平均浓度分别为2170（标准差570）和2510（标准差2230）mg/L，非糖尿病患者分别为2230（标准差560）和2210（标准差1830）mg/L。糖尿病受试者的血浆甘油三酯浓度与餐前血糖或糖化血红蛋白值之间呈正相关（分别为P<0.02和<0.01）。糖尿病患者和非糖尿病患者VLDL中甘油三酯、胆固醇以及载脂蛋白（apo）B、CII、CIII和E的浓度无显著差异。在可比的甘油三酯浓度下，两组VLDL的化学组成仍然非常相似。将各组分的浓度除以VLDL-apo B浓度，两组每单位VLDL中各组分的含量相似。我们得出结论，在血浆甘油三酯浓度可比的情况下，糖尿病患者VLDL的组成与非糖尿病患者的非常相同。
