Balin A K, Pratt L A
Laboratory for Investigative Dermatology, Rockefeller University, New York, New York 10021.
Cutis. 1989 May;43(5):431-6.
The expression and treatment of cutaneous disease in the elderly differ from those applicable to younger adults. Anatomical changes in aging skin result in altered physiological behavior and susceptibility to disease. Decreased epidermal renewal and tissue repair accompany the aging process. The rate of hair and nail growth declines, as well as the quantity of eccrine, apocrine, and sebum secretion. There are alterations in immune surveillance and antigen presentation with aging. The cutaneous vascular supply is decreased, leading to decreases in inflammatory response, absorption, and cutaneous clearance. Impaired thermal regulation, tactile sensitivity, and pain perception occur as one ages. We summarize the major changes that occur during the intrinsic aging process of the skin to facilitate the recognition and treatment of skin disease in the older patient.
老年人皮肤病的表现和治疗与年轻人不同。衰老皮肤的解剖学变化导致生理行为改变和疾病易感性增加。衰老过程伴随着表皮更新和组织修复能力下降。毛发和指甲的生长速度以及外分泌腺、顶泌汗腺和皮脂分泌量均下降。随着年龄增长，免疫监视和抗原呈递也会发生改变。皮肤血管供应减少，导致炎症反应、吸收和皮肤清除能力下降。随着年龄增长，体温调节、触觉敏感性和疼痛感知都会受损。我们总结了皮肤自然衰老过程中发生的主要变化，以促进老年患者皮肤病的识别和治疗。
