学龄儿童不同年龄组口腔念珠菌与龋指数的量化及相关性：一项病例对照研究。
Quantification and Correlation of Oral Candida with Caries Index Among Different Age Groups of School Children: A Case-Control Study.
作者信息
Naidu B V, Reginald B A
机构信息
Department of Oral Pathology, Anil Neerukonda Institute of Dental Sciences, Sanghivalasa, Visakhapatnam, Andhra Pradesh, India.
Department of Oral and Maxillofacial Pathology, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India.
出版信息
Ann Med Health Sci Res. 2016 Mar-Apr;6(2):80-4. doi: 10.4103/2141-9248.181843.
BACKGROUND
Dental caries is the most common infectious disease affecting humans and is the predominant cause of tooth loss in children. Although Candida's role in dental caries has been studied extensively, limited homogenous studies have been conducted and none have been found, that associate Candida with dental caries, while correlating it to different age groups.
AIM
The study aimed to quantify oral Candida in school children and correlate candidal carriage to the caries index and further analyze an age association.
SUBJECTS AND METHODS
Decayed-Filled teeth/Decayed-Missing-Filled Teeth (dft/DMFT) index scores of 150 subjects were evaluated, and concentrated oral rinse samples were collected from each participant for mycologic investigation. Based on the age and caries activity, the participants were categorized into three groups consisting of 50 each such as Group-I (caries active participants of 6-12 years age), Group-II (caries active participants in 13-18 years age), and Group-III (caries-free participants in 6-18 years age); CHROMagar™ was used as a primary culture medium for candidal growth. The data was statistically analyzed using Unpaired t-test, Chi-square test and Spearman's rank order.
RESULTS
The results demonstrated that as age increases, the dft/DMFT scores as well as the candidal growth decreased. In addition, the oral candidal carriage levels were found to be low in caries-free group (Group-III) when compared to the study groups.
CONCLUSION
The presence of Candida was directly related to the caries status and inversely proportional to the age.
背景
龋齿是影响人类最常见的传染病，也是儿童牙齿脱落的主要原因。尽管念珠菌在龋齿中的作用已得到广泛研究，但相关的同类研究有限，尚未发现将念珠菌与龋齿相关联并将其与不同年龄组相关联的研究。
目的
本研究旨在量化学龄儿童口腔念珠菌，并将念珠菌携带情况与龋齿指数相关联，进一步分析年龄关联。
对象与方法
评估150名受试者的龋补牙数/龋失补牙数（dft/DMFT）指数得分，并从每位参与者收集浓缩口腔冲洗样本进行真菌学调查。根据年龄和龋齿活动情况，将参与者分为三组，每组50人，即第一组（6至12岁的龋齿活跃参与者）、第二组（13至18岁的龋齿活跃参与者）和第三组（6至18岁的无龋参与者）；CHROMagar™用作念珠菌生长的主要培养基。使用非配对t检验、卡方检验和Spearman等级顺序对数据进行统计分析。
结果
结果表明，随着年龄的增加，dft/DMFT得分以及念珠菌生长均下降。此外，与研究组相比，无龋组（第三组）的口腔念珠菌携带水平较低。
结论
念珠菌的存在与龋齿状况直接相关，与年龄成反比。
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