Ma Yuan, Mou Quanbing, Wang Dali, Zhu Xinyuan, Yan Deyue
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China.
Theranostics. 2016 Apr 27;6(7):930-47. doi: 10.7150/thno.14855. eCollection 2016.
Dendritic polymers are highly branched polymers with controllable structures, which possess a large population of terminal functional groups, low solution or melt viscosity, and good solubility. Their size, degree of branching and functionality can be adjusted and controlled through the synthetic procedures. These tunable structures correspond to application-related properties, such as biodegradability, biocompatibility, stimuli-responsiveness and self-assembly ability, which are the key points for theranostic applications, including chemotherapeutic theranostics, biotherapeutic theranostics, phototherapeutic theranostics, radiotherapeutic theranostics and combined therapeutic theranostics. Up to now, significant progress has been made for the dendritic polymers in solving some of the fundamental and technical questions toward their theranostic applications. In this review, we briefly summarize how to control the structures of dendritic polymers, the theranostics-related properties derived from their structures and their theranostics-related applications.
树枝状聚合物是具有可控结构的高度支化聚合物,其具有大量末端官能团、低溶液或熔体粘度以及良好的溶解性。它们的尺寸、支化度和官能度可以通过合成过程进行调节和控制。这些可调节的结构对应于与应用相关的性质,如生物可降解性、生物相容性、刺激响应性和自组装能力,这些是治疗诊断应用的关键点,包括化疗治疗诊断、生物治疗诊断、光疗治疗诊断、放射治疗诊断和联合治疗诊断。到目前为止,树枝状聚合物在解决其治疗诊断应用的一些基本和技术问题方面已经取得了重大进展。在这篇综述中,我们简要总结了如何控制树枝状聚合物的结构、由其结构衍生的与治疗诊断相关的性质以及它们与治疗诊断相关的应用。