Epigenetic drugs: from chemistry via biology to medicine and back.
作者信息
Altucci Lucia, Rots Marianne G
机构信息
Seconda Università degli Studi di Napoli, Dipartimento di Biochimica, Biofisica e Patologia generale, Vico L. De Crecchio 7, Napoli, 80138 Italy.
University Medical Center Groningen, Groningen, Netherlands.
出版信息
Clin Epigenetics. 2016 May 23;8:56. doi: 10.1186/s13148-016-0222-5. eCollection 2016.
Abstract
摘要
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Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase.局部染色质微环境决定DNA甲基转移酶活性：从DNA甲基转移酶到DNA去甲基酶或DNA去羟甲基酶。
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Long-term use of valproic acid in US veterans is associated with a reduced risk of smoking-related cases of head and neck cancer.在美国退伍军人中，长期使用丙戊酸与降低与吸烟有关的头颈部癌症病例的风险有关。
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