慢性牙周炎患者牙龈组织中一种新型微小双链环状DNA病毒（TTMV）。
A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients.
作者信息
Zhang Yu, Li Fei, Shan Tong-Ling, Deng Xutao, Delwart Eric, Feng Xi-Ping
机构信息
Department of Preventive Dentistry, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
Department of Swine Infectious Disease, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
出版信息
Sci Rep. 2016 May 25;6:26739. doi: 10.1038/srep26739.
A new species of torque teno mini virus, named TTMV-222, was detected in gingival tissue from periodontitis patients using a viral metagenomics method. The 2803-nucleotide genome of TTMV-222 is closely related to TTMV1-CBD279, with 62.6% overall nucleotide similarity. Genetic analyses of the new virus genome revealed a classic genomic organization but a weak identity with known sequences. The prevalence of TTMV-222 in the periodontitis group (n = 150) was significantly higher than that in the healthy group (n = 150) (p = 0.032), suggesting that the new virus may be associated with inflammation in chronic periodontitis patients. However, this finding requires further investigation.
利用病毒宏基因组学方法，在牙周炎患者的牙龈组织中检测到一种新型的细小病毒属微小病毒，命名为TTMV-222。TTMV-222的2803个核苷酸基因组与TTMV1-CBD279密切相关，总体核苷酸相似性为62.6%。对新病毒基因组的遗传分析揭示了一种经典的基因组结构，但与已知序列的同源性较低。TTMV-222在牙周炎组（n = 150）中的流行率显著高于健康组（n = 150）（p = 0.032），这表明这种新病毒可能与慢性牙周炎患者的炎症有关。然而，这一发现需要进一步研究。
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