Zhang Yu, Li Fei, Chen Xi, Shan Tong-Ling, Deng Xu-Tao, Delwart Eric, Feng Xi-Ping
Department of Preventive Dentistry, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.
Department of Swine Infectious Disease, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
Virus Genes. 2017 Dec;53(6):823-830. doi: 10.1007/s11262-017-1505-4. Epub 2017 Sep 2.
We describe a novel species of torque teno mini virus called TTMV-204, which was isolated from the gingival epithelium of patients with periodontitis and characterized using viral metagenomics. The sequence of the full genome is 2824 nt in length. Phylogenetic analysis and genetic analyses show classic Betatorquevirus species organization with less than 40% amino acid similarity in ORF1. The prevalence of TTMV-204 in the periodontitis patient population was 18.75% (15/80), which was higher than in periodontally healthy individuals (10.00%, 10/80). However, the difference of the TTMV-204 prevalence between two groups was not statistically significant (p = 0.115). Further investigation is required to determine whether this new virus is associated with inflammation.
我们描述了一种新型的细小病毒属微小病毒，称为TTMV-204，它是从牙周炎患者的牙龈上皮中分离出来的，并通过病毒宏基因组学进行了表征。全基因组序列长度为2824个核苷酸。系统发育分析和遗传分析显示，其具有典型的戊型细小病毒属物种结构，开放阅读框1中的氨基酸相似性低于40%。TTMV-204在牙周炎患者群体中的流行率为18.75%（15/80），高于牙周健康个体（10.00%，10/80）。然而，两组之间TTMV-204流行率的差异无统计学意义（p = 0.115）。需要进一步研究以确定这种新病毒是否与炎症相关。
