Yu Tian, Zhang Yu, Pan Shao-Kun, Yang Bin, Feng Xi-Ping
Department of Preventive Dentistry, Shanghai Stomatological Hospital; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University. Shanghai 200001, China. E-mail:
Shanghai Kou Qiang Yi Xue. 2022 Dec;31(6):632-637.
To study the prevalence of torque teno mini virus (TTMV) and epstein-barr virus(EBV) in patients with periodontitis.
Gingival tissue samples were collected from 80 patients with periodontitis and 40 periodontal healthy volunteers. The presence of EBV and TTMV-222 were detected by nested PCR, and the virus loads were detected by real-time PCR. Statistical analysis was performed by SPSS 16.0 software package.
The detection rates and virus loads of EBV and TTMV-222 in periodontitis group were significantly higher than those in periodontal health group (P＜0.05), and the detection rate of TTMV-222 in EBV positive group was significantly higher than that in EBV negative group (P＜0.01). There was a positive correlation between EBV and TTMV-222 in gingival tissues(P＜0.01).
TTMV infection and co-infection of EBV and TTMV may be related to periodontal disease, but the pathogenic mechanism of the interaction between the two viruses needs further studies.
研究微小病毒B19（TTMV）和爱泼斯坦-巴尔病毒（EBV）在牙周炎患者中的感染率。
收集80例牙周炎患者和40例牙周健康志愿者的牙龈组织样本。采用巢式PCR检测EBV和TTMV-222的存在情况，采用实时PCR检测病毒载量。使用SPSS 16.0软件包进行统计分析。
牙周炎组EBV和TTMV-222的检出率及病毒载量均显著高于牙周健康组（P＜0.05），EBV阳性组TTMV-222的检出率显著高于EBV阴性组（P＜0.01）。牙龈组织中EBV与TTMV-222呈正相关（P＜0.01）。
TTMV感染以及EBV与TTMV的共同感染可能与牙周疾病有关，但两种病毒相互作用的致病机制有待进一步研究。
