与特应性、嗜酸性食管炎及修正的TH2反应相关的IgE和IgG4抗体的发育史
The Developmental History of IgE and IgG4 Antibodies in Relation to Atopy, Eosinophilic Esophagitis, and the Modified TH2 Response.
作者信息
Aalberse Rob C, Platts-Mills Thomas A, Rispens Theo
机构信息
Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, P.O. Box 9190, 1006 AD, Amsterdam, The Netherlands.
Division of Allergy and Immunology, University of Virginia, Charlottesville, VA, USA.
出版信息
Curr Allergy Asthma Rep. 2016 Jun;16(6):45. doi: 10.1007/s11882-016-0621-x.
Abstract
A common reaction from anyone confronted with allergy is the question: what prevents universal allergy? We will discuss recent findings in the mouse system that have provided us with clues on why allergy is not more common. We will also address one crucial aspect of atopic allergy in humans, which is absent in most mouse model systems, an IgG/IgE ratio <10. We consider the typical mouse IgE response to be more closely related to the "modified TH2" response in humans. We will discuss the similarities and differences between the IgE and IgG4 response to allergens and an update on the IgG4 B cell, partly derived from studies on eosinophilic esophagitis and IgG4-related diseases.
摘要
任何面临过敏问题的人常见的反应都是这个问题
是什么阻止了普遍过敏？我们将讨论在小鼠系统中的最新发现，这些发现为我们提供了关于为什么过敏不那么常见的线索。我们还将探讨人类特应性过敏的一个关键方面，这在大多数小鼠模型系统中是不存在的，即IgG/IgE比率<10。我们认为典型的小鼠IgE反应与人类的“改良TH2”反应更密切相关。我们将讨论IgE和IgG4对过敏原反应的异同，以及IgG4 B细胞的最新情况，部分内容源于对嗜酸性食管炎和IgG4相关疾病的研究。
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