Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, North Terrace, 5000, Adelaide, SA, Australia.
Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Dig Dis Sci. 2021 Dec;66(12):4099-4108. doi: 10.1007/s10620-020-06788-0. Epub 2021 Feb 3.
Our knowledge of the pathophysiology of eosinophilic esophagitis is constantly evolving. There is significant association between eosinophilic esophagitis and atopy; however, multiple studies have refuted the role of IgE in its pathogenesis. Instead, new data have demonstrated an elevated IgG4 level in patients with eosinophilic esophagitis. We review the current understanding of eosinophilic esophagitis pathogenesis and highlight the increasing evidence for the role of IgG4.
我们对嗜酸性粒细胞性食管炎病理生理学的认识在不断发展。嗜酸性粒细胞性食管炎与特应性有密切关联，但多项研究反驳了 IgE 在其发病机制中的作用。相反，新数据显示，嗜酸性粒细胞性食管炎患者的 IgG4 水平升高。我们综述了目前对嗜酸性粒细胞性食管炎发病机制的认识，并强调了 IgG4 作用的证据不断增加。
